UMass Chan AffiliationsEmery Lab
Document TypeBook Chapter
Neuroscience and Neurobiology
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AbstractForward genetics in Drosophila has profoundly affected our understanding of circadian rhythms in this organism and, more generally, in the animal kingdom. Most Drosophila pacemaker genes were discovered through the isolation of gene variants affecting the free-running period of the circadian pacemaker. There are different ways to mutagenize flies. An alkylating agent can be used to randomly alter the fly genome, or transposable elements can be mobilized to disrupt or increase the expression of the targeted genes. The advantages of these different methods are complementary.
SourceMethods Mol Biol. 2007;362:187-95. DOI 10.1007/978-1-59745-257-1_13
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/38021
Related ResourcesLink to Article in PubMed