Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity
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UMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience ProgramLee Lab
Neurobiology
Document Type
Journal ArticlePublication Date
2006-10-20Keywords
5' Untranslated RegionsAmino Acid Sequence
Animals
Brain
Cell Differentiation
Cell Lineage
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Larva
Molecular Sequence Data
Morphogenesis
Mushroom Bodies
Mutation
Nerve Tissue Proteins
*Neurons
*Protein Processing, Post-Translational
Time Factors
Transgenes
*Zinc Fingers
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
Many neural progenitors, including Drosophila mushroom body (MB) and projection neuron (PN) neuroblasts, sequentially give rise to different subtypes of neurons throughout development. We identified a novel BTB-zinc finger protein, named Chinmo (Chronologically inappropriate morphogenesis), that governs neuronal temporal identity during postembryonic development of the Drosophila brain. In both MB and PN lineages, loss of Chinmo autonomously causes early-born neurons to adopt the fates of late-born neurons from the same lineages. Interestingly, primarily due to a posttranscriptional control, MB neurons born at early developmental stages contain more abundant Chinmo than their later-born siblings. Further, the temporal identity of MB progeny can be transformed toward earlier or later fates by reducing or increasing Chinmo levels, respectively. Taken together, we suggest that a temporal gradient of Chinmo (Chinmo(high) --> Chinmo(low)) helps specify distinct birth order-dependent cell fates in an extended neuronal lineage.Source
Cell. 2006 Oct 20;127(2):409-22. Link to article on publisher's siteDOI
10.1016/j.cell.2006.08.045Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38023PubMed ID
17055440Notes
Co-author Suewei Lin is a student in the Neuroscience program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2006.08.045