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    A clock shock: mouse CLOCK is not required for circadian oscillator function

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    Authors
    DeBruyne, Jason P.
    Noton, Elizabeth
    Lambert, Christopher M.
    Maywood, Elizabeth S.
    Weaver, David R.
    Reppert, Steven M.
    UMass Chan Affiliations
    Weaver Lab
    Reppert Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2006-05-04
    Keywords
    ARNTL Transcription Factors
    Animals
    Basic Helix-Loop-Helix Transcription Factors
    Biological Clocks
    CLOCK Proteins
    Circadian Rhythm
    Dimerization
    Feedback, Physiological
    Light
    Liver
    Mice
    Mice, Inbred C57BL
    Mice, Knockout
    Mice, Transgenic
    Motor Activity
    Phenotype
    Photic Stimulation
    RNA, Messenger
    Suprachiasmatic Nucleus
    Trans-Activators
    Neuroscience and Neurobiology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.neuron.2006.03.041
    Abstract
    The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant circadian phenotypes. Surprisingly, CLOCK-deficient mice continue to express robust circadian rhythms in locomotor activity, although they do have altered responses to light. At the molecular and biochemical levels, clock gene mRNA and protein levels in both the master clock in the suprachiasmatic nuclei and a peripheral clock in the liver show alterations in the CLOCK-deficient animals, although the molecular feedback loops continue to function. Our data challenge a central feature of the current mammalian circadian clock model regarding the necessity of CLOCK:BMAL1 heterodimers for clock function.
    Source
    Neuron. 2006 May 4;50(3):465-77. Link to article on publisher's site
    DOI
    10.1016/j.neuron.2006.03.041
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38024
    PubMed ID
    16675400
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuron.2006.03.041
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    Neurobiology Faculty Publications

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