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dc.contributor.authorZheng, Xiaoyan
dc.contributor.authorZugates, Christopher T.
dc.contributor.authorLu, Zouyan
dc.contributor.authorShi, Lei
dc.contributor.authorBai, Jia-Min
dc.contributor.authorLee, Tzumin
dc.date2022-08-11T08:09:30.000
dc.date.accessioned2022-08-23T16:33:06Z
dc.date.available2022-08-23T16:33:06Z
dc.date.issued2006-02-08
dc.date.submitted2012-05-24
dc.identifier.citationEMBO J. 2006 Feb 8;25(3):615-27. Epub 2006 Jan 26. <a href="http://dx.doi.org/10.1038/sj.emboj.7600962">Link to article on publisher's site</a>
dc.identifier.issn0261-4189 (Linking)
dc.identifier.doi10.1038/sj.emboj.7600962
dc.identifier.pmid16437159
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38027
dc.description<p>Co-author Lei Shi is a student in the Neuroscience program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.</p>
dc.description.abstractThe intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the adult Drosophila brain. To better understand this process, we characterized the development of a dorsal cluster (DC) of Atonal-positive neurons that are born at early larval stages but do not undergo extensive morphogenesis until pupal formation. We found that Baboon(Babo)/dSmad2-mediated TGF-beta signaling, known to be essential for remodeling of larval functional neurons, is also indispensable for proper morphogenesis of these adult-specific neurons. Mosaic analysis reveals slowed development of mutant DC neurons, as evidenced by delays in both neuronal morphogenesis and atonal expression. We observe similar phenomena in other adult-specific neurons. We further demonstrate that Babo/dSmad2 operates autonomously in individual neurons and specifically during the late larval stage. Our results suggest that Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16437159&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383542/pdf/7600962a.pdf
dc.subjectActivin Receptors, Type I
dc.subjectActivin Receptors, Type II
dc.subjectActivins
dc.subjectAnimals
dc.subjectDrosophila Proteins
dc.subjectDrosophila melanogaster
dc.subjectLarva
dc.subjectMetamorphosis, Biological
dc.subjectMorphogenesis
dc.subjectMutation
dc.subjectNeurons
dc.subjectProtein-Serine-Threonine Kinases
dc.subjectReceptors, Transforming Growth Factor beta
dc.subjectSignal Transduction
dc.subjectSmad2 Protein
dc.subjectTransforming Growth Factor beta
dc.subjectDevelopmental Neuroscience
dc.titleBaboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons
dc.typeJournal Article
dc.source.journaltitleThe EMBO journal
dc.source.volume25
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neurobiology_pp/60
dc.identifier.contextkey2911175
html.description.abstract<p>The intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the adult Drosophila brain. To better understand this process, we characterized the development of a dorsal cluster (DC) of Atonal-positive neurons that are born at early larval stages but do not undergo extensive morphogenesis until pupal formation. We found that Baboon(Babo)/dSmad2-mediated TGF-beta signaling, known to be essential for remodeling of larval functional neurons, is also indispensable for proper morphogenesis of these adult-specific neurons. Mosaic analysis reveals slowed development of mutant DC neurons, as evidenced by delays in both neuronal morphogenesis and atonal expression. We observe similar phenomena in other adult-specific neurons. We further demonstrate that Babo/dSmad2 operates autonomously in individual neurons and specifically during the late larval stage. Our results suggest that Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis.</p>
dc.identifier.submissionpathneurobiology_pp/60
dc.contributor.departmentGraduate School of Biomedical Sciences, Neuroscience Program
dc.contributor.departmentLee Lab
dc.contributor.departmentNeurobiology
dc.source.pages615-27
dc.contributor.studentLei Shi
dc.description.thesisprogramNeuroscience


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