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dc.contributor.authorFreeman, Marc R.
dc.date2022-08-11T08:09:30.000
dc.date.accessioned2022-08-23T16:33:07Z
dc.date.available2022-08-23T16:33:07Z
dc.date.issued2006-02-01
dc.date.submitted2012-05-24
dc.identifier.citationCurr Opin Neurobiol. 2006 Feb;16(1):119-25. Epub 2006 Jan 4. <a href="http://dx.doi.org/10.1016/j.conb.2005.12.004">Link to article on publisher's site</a>
dc.identifier.issn0959-4388 (Linking)
dc.identifier.doi10.1016/j.conb.2005.12.004
dc.identifier.pmid16387489
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38028
dc.description.abstractGlial cells are not passive spectators during nervous system assembly, rather they are active participants that exert significant control over neuronal development. Well-established roles for glia in shaping the developing nervous system include providing trophic support to neurons, modulating axon pathfinding, and driving nerve fasciculation. Exciting recent studies have revealed additional ways in which glial cells also modulate neurodevelopment. Glial cells regulate the number of neurons at early developmental stages by dynamically influencing neural precursor divisions, and at later stages by promoting neuronal cell death through engulfment. Glia also participate in the fine sculpting of neuronal connections by pruning excess axonal projections, shaping dendritic spines, and secreting multiple factors that promote synapse formation and functional maturation. These recent insights provide further compelling evidence that glial cells, through their diverse cellular actions, are essential contributors to the construction of a functionally mature nervous system.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16387489&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.conb.2005.12.004
dc.subjectAnimals
dc.subjectAxons
dc.subjectCell Death
dc.subjectDendrites
dc.subjectNervous System
dc.subjectNeuroglia
dc.subjectNeurons
dc.subjectStem Cells
dc.subjectSynapses
dc.subjectNeuroscience and Neurobiology
dc.titleSculpting the nervous system: glial control of neuronal development
dc.typeJournal Article
dc.source.journaltitleCurrent opinion in neurobiology
dc.source.volume16
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neurobiology_pp/61
dc.identifier.contextkey2911176
html.description.abstract<p>Glial cells are not passive spectators during nervous system assembly, rather they are active participants that exert significant control over neuronal development. Well-established roles for glia in shaping the developing nervous system include providing trophic support to neurons, modulating axon pathfinding, and driving nerve fasciculation. Exciting recent studies have revealed additional ways in which glial cells also modulate neurodevelopment. Glial cells regulate the number of neurons at early developmental stages by dynamically influencing neural precursor divisions, and at later stages by promoting neuronal cell death through engulfment. Glia also participate in the fine sculpting of neuronal connections by pruning excess axonal projections, shaping dendritic spines, and secreting multiple factors that promote synapse formation and functional maturation. These recent insights provide further compelling evidence that glial cells, through their diverse cellular actions, are essential contributors to the construction of a functionally mature nervous system.</p>
dc.identifier.submissionpathneurobiology_pp/61
dc.contributor.departmentFreeman Lab
dc.contributor.departmentNeurobiology
dc.source.pages119-25


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