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Prevention of diabetes in BB/Wor rats by intrathymic islet injection

dc.contributor.authorKoevary, Steven B.
dc.contributor.authorBlomberg, Maureen
dc.date2022-08-11T08:09:30.000
dc.date.accessioned2022-08-23T16:33:30Z
dc.date.available2022-08-23T16:33:30Z
dc.date.issued1992-02-01
dc.date.submitted2008-10-31
dc.identifier.citationJ Clin Invest. 1992 Feb;89(2):512-6. <a href="http://dx.doi.org/10.1172/JCI115614">Link to article on publisher's site</a>
dc.identifier.issn0021-9738 (Print)
dc.identifier.doi10.1172/JCI115614
dc.identifier.pmid1737841
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38121
dc.description.abstractThe objective of this study was to determine whether the intrathymic injection of islets can prevent the development of diabetes in BB/Wor rats. Evidence suggests that a failure to induce islet thymic tolerance may be an etiological factor in the development of the disease. It was theorized that the introduction of islets into the thymus might directly induce islet tolerance and thus prevent disease. Islets from diabetes-resistant BB/Wor rats were injected into the thymuses of 23 young diabetes-prone BB/Wor rats; 25 sham-operated animals served as controls. Results showed that 22 of the 25 control rats became diabetic while only 8 of the 23 experimental rats became diabetic (P less than 0.0002). The specific lysis of islet cells by spleen cells from nondiabetic experimental and control rats was comparable and less than the lysis induced by spleen cells from diabetic rats. These data demonstrate that the intrathymic injection of islets into diabetes-prone BB/Wor rats is an effective method for preventing the development of autoimmune type I diabetes.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=1737841&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAnimals
dc.subjectAutoimmune Diseases
dc.subjectCytotoxicity, Immunologic
dc.subjectDiabetes Mellitus, Type 1
dc.subjectImmune Tolerance
dc.subjectIslets of Langerhans
dc.subject*Islets of Langerhans Transplantation
dc.subjectRats
dc.subjectRats, Inbred BB
dc.subjectThymus Gland
dc.subjectCell Biology
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.titlePrevention of diabetes in BB/Wor rats by intrathymic islet injection
dc.typeJournal Article
dc.source.journaltitleThe Journal of clinical investigation
dc.source.volume89
dc.source.issue2
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2006&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1007
dc.identifier.contextkey659190
refterms.dateFOA2022-08-23T16:33:30Z
html.description.abstract<p>The objective of this study was to determine whether the intrathymic injection of islets can prevent the development of diabetes in BB/Wor rats. Evidence suggests that a failure to induce islet thymic tolerance may be an etiological factor in the development of the disease. It was theorized that the introduction of islets into the thymus might directly induce islet tolerance and thus prevent disease. Islets from diabetes-resistant BB/Wor rats were injected into the thymuses of 23 young diabetes-prone BB/Wor rats; 25 sham-operated animals served as controls. Results showed that 22 of the 25 control rats became diabetic while only 8 of the 23 experimental rats became diabetic (P less than 0.0002). The specific lysis of islet cells by spleen cells from nondiabetic experimental and control rats was comparable and less than the lysis induced by spleen cells from diabetic rats. These data demonstrate that the intrathymic injection of islets into diabetes-prone BB/Wor rats is an effective method for preventing the development of autoimmune type I diabetes.</p>
dc.identifier.submissionpathoapubs/1007
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages512-6


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