Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption
UMass Chan Affiliations
Department of AnatomyDocument Type
Journal ArticlePublication Date
1987-11-01Keywords
Acid PhosphataseAlveolar Process
Animals
*Bone Resorption
Dental Sac
Dogs
Histocytochemistry
Osteoclasts
Tartrates
*Tooth Eruption
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Tartrate-resistant acid phosphatase (TRAP) has been used as a cytochemical marker for the cell mediators of bone resorption, osteoclasts and their mononuclear precursors. We have applied a cytochemical method for TRAP to study the dependence of the osteoclast-mediated bone resorption of tooth eruption on the dental follicle, a connective tissue investment of the developing tooth, by analyzing the TRAP activity of mononuclear cells in the dental follicle before and during pre-molar eruption in dogs. The percentage of TRAP-positive monocyte cells increases until mid-eruption, slightly preceding a previously demonstrated rise in numbers of osteoclasts on adjacent bone surfaces. These data suggest an ontogenetic relationship between follicular mononuclear cells and osteoclasts on adjacent alveolar bone surfaces during tooth eruption. However, because TRAP occurs in other tissues and is not an exclusive indicator of pre-osteoclasts, proof of their relationship will have to await application of more definitive techniques.Source
J Histochem Cytochem. 1987 Nov;35(11):1227-30.
DOI
10.1177/35.11.3655324Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38199PubMed ID
3655324Related Resources
ae974a485f413a2113503eed53cd6c53
10.1177/35.11.3655324