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dc.contributor.authorRossetti, Ronald G.
dc.contributor.authorSeiler, Christina M.
dc.contributor.authorDeLuca, Pamela
dc.contributor.authorLaposata, Michael
dc.contributor.authorZurier, Robert
dc.date2022-08-11T08:09:31.000
dc.date.accessioned2022-08-23T16:34:10Z
dc.date.available2022-08-23T16:34:10Z
dc.date.issued1997-10-23
dc.date.submitted2009-03-10
dc.identifier.citation<p>J Leukoc Biol. 1997 Oct;62(4):438-43.</p>
dc.identifier.issn0741-5400 (Print)
dc.identifier.doi10.1002/jlb.62.4.438
dc.identifier.pmid9335312
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38271
dc.description.abstractOils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis (RA) patients. Because T lymphocyte activation is important to propagation of joint tissue injury in patients with RA, we examined the effects of fatty acids administered by mouth in vivo on proliferation of human lymphocytes activated through the T cell receptor complex. T cell proliferation was reduced after oral administration of 2.4 g gammalinolenic acid in capsules of borage seed oil. Oral administration of oils enriched in linoleic acid, the parent n-6 fatty acid, and alpha linolenic acid, the parent n-3 fatty acid, did not influence growth of stimulated cells. Fatty acid analyses indicated that suppression of lymphocyte proliferation after gammalinolenic acid administration was associated with increased plasma and peripheral blood mononuclear cell concentrations of gammalinolenic acid and dihomogammalinolenic acid.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=9335312&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1002/jlb.62.4.438
dc.subjectAdministration, Oral
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectDietary Fats, Unsaturated
dc.subjectFlax
dc.subjectHelianthus
dc.subjectHumans
dc.subjectLymphocyte Activation
dc.subjectPlant Oils
dc.subjectSafflower Oil
dc.subjectT-Lymphocytes
dc.subjectTime Factors
dc.subjectgamma-Linolenic Acid
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleOral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation
dc.typeArticle
dc.source.journaltitleJournal of leukocyte biology
dc.source.volume62
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1144
dc.identifier.contextkey770122
html.description.abstract<p>Oils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis (RA) patients. Because T lymphocyte activation is important to propagation of joint tissue injury in patients with RA, we examined the effects of fatty acids administered by mouth in vivo on proliferation of human lymphocytes activated through the T cell receptor complex. T cell proliferation was reduced after oral administration of 2.4 g gammalinolenic acid in capsules of borage seed oil. Oral administration of oils enriched in linoleic acid, the parent n-6 fatty acid, and alpha linolenic acid, the parent n-3 fatty acid, did not influence growth of stimulated cells. Fatty acid analyses indicated that suppression of lymphocyte proliferation after gammalinolenic acid administration was associated with increased plasma and peripheral blood mononuclear cell concentrations of gammalinolenic acid and dihomogammalinolenic acid.</p>
dc.identifier.submissionpathoapubs/1144
dc.contributor.departmentDepartment of Medicine, Division of Rheumatology
dc.source.pages438-43


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