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dc.contributor.authorFebo, Marcelo
dc.contributor.authorFerris, Craig F.
dc.contributor.authorSegarra, Annabell C.
dc.date2022-08-11T08:09:31.000
dc.date.accessioned2022-08-23T16:34:17Z
dc.date.available2022-08-23T16:34:17Z
dc.date.issued2005-02-04
dc.date.submitted2009-03-10
dc.identifier.citationJ Neurosci. 2005 Feb 2;25(5):1132-6. <a href="http://dx.doi.org/10.1523/JNEUROSCI.3801-04.2005">Link to article on publisher's site</a>
dc.identifier.issn1529-2401 (Electronic)
dc.identifier.doi10.1523/JNEUROSCI.3801-04.2005
dc.identifier.pmid15689549
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38298
dc.description.abstractWe investigated the effect of estrogen on cocaine-induced brain activity using blood oxygen level-dependent (BOLD) magnetic resonance imaging. Ovariectomized (Ovx) rats without estrogen and Ovx rats with estrogen (Ovx+E) were given a single saline or cocaine injection (15 mg/kg, i.p.) for 5 d. After 7 d of withdrawal from injections, rats were challenged with cocaine during functional imaging. Acute cocaine administration produced positive BOLD activation in the prefrontal cortex, nucleus accumbens, striatum, ventral tegmental area, and hippocampus, among other brain regions. Positive BOLD signal changes were lower in Ovx+E than in Ovx rats. With repeated cocaine administration, Ovx+E rats showed enhanced BOLD signal changes in the nucleus accumbens, ventral tegmental area, and hippocampus compared with acutely treated animals. Our results indicate that estrogen influences the effects of acute and repeated cocaine administration on BOLD signal changes. The data suggest that in females with estrogen, cocaine-induced neuronal activity is enhanced after repeated cocaine administration. It is possible that the actions of estrogen within the aforementioned brain regions potentiate the behavioral response to cocaine observed in female rats.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15689549&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAnimals
dc.subjectCerebrovascular Circulation
dc.subjectCocaine
dc.subjectEstradiol
dc.subjectFemale
dc.subjectHippocampus
dc.subjectHypercapnia
dc.subjectMagnetic Resonance Imaging
dc.subjectNucleus Accumbens
dc.subjectOvariectomy
dc.subjectOxygen
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSex Characteristics
dc.subjectTegmentum Mesencephali
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleEstrogen influences cocaine-induced blood oxygen level-dependent signal changes in female rats
dc.typeJournal Article
dc.source.journaltitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
dc.source.volume25
dc.source.issue5
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2168&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1169
dc.identifier.contextkey770147
refterms.dateFOA2022-08-23T16:34:17Z
html.description.abstract<p>We investigated the effect of estrogen on cocaine-induced brain activity using blood oxygen level-dependent (BOLD) magnetic resonance imaging. Ovariectomized (Ovx) rats without estrogen and Ovx rats with estrogen (Ovx+E) were given a single saline or cocaine injection (15 mg/kg, i.p.) for 5 d. After 7 d of withdrawal from injections, rats were challenged with cocaine during functional imaging. Acute cocaine administration produced positive BOLD activation in the prefrontal cortex, nucleus accumbens, striatum, ventral tegmental area, and hippocampus, among other brain regions. Positive BOLD signal changes were lower in Ovx+E than in Ovx rats. With repeated cocaine administration, Ovx+E rats showed enhanced BOLD signal changes in the nucleus accumbens, ventral tegmental area, and hippocampus compared with acutely treated animals. Our results indicate that estrogen influences the effects of acute and repeated cocaine administration on BOLD signal changes. The data suggest that in females with estrogen, cocaine-induced neuronal activity is enhanced after repeated cocaine administration. It is possible that the actions of estrogen within the aforementioned brain regions potentiate the behavioral response to cocaine observed in female rats.</p>
dc.identifier.submissionpathoapubs/1169
dc.contributor.departmentCenter for Comparative NeuroImaging
dc.source.pages1132-6


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