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dc.contributor.authorYvon, Delville
dc.contributor.authorMelloni, Richard H.
dc.contributor.authorFerris, Craig F.
dc.date2022-08-11T08:09:32.000
dc.date.accessioned2022-08-23T16:34:21Z
dc.date.available2022-08-23T16:34:21Z
dc.date.issued1998-04-16
dc.date.submitted2009-03-10
dc.identifier.citationJ Neurosci. 1998 Apr 1;18(7):2667-72.
dc.identifier.issn0270-6474 (Print)
dc.identifier.pmid9502824
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38309
dc.description.abstractIn golden hamsters, offensive aggression is facilitated by vasopressin and inhibited by serotonin. We tested whether these neurotransmitter systems respond to modifications resulting from the stress of threat and attack (i.e., social subjugation) during puberty. Male golden hamsters were weaned at postnatal day 25 (P25), exposed daily to aggressive adults from P28 to P42, and tested for offensive aggression as young adults (P45). The results showed a context-dependent alteration in aggressive behavior. Subjugated animals were more likely to attack younger and weaker intruders than nonsubjugated controls. Conversely, subjugated animals were less likely to attack animals of similar size and age. After testing, the animals were killed, and their brains were collected to determine whether these behavioral changes are underlined by changes in the vasopressin and serotonin systems. Social subjugation resulted in a 50% decrease in vasopressin levels within the anterior hypothalamus, a site involved in the regulation of aggression. Furthermore, whereas the density of vasopressin-immunoreactive fibers within the area was not significantly altered in subjugated animals, the number of serotonin-immunoreactive varicosities within the anterior hypothalamus and lateral septum was 20% higher in subjugated animals than in their controls. These results establish puberty as a developmental period sensitive to environmental stressors. Furthermore, the results show that changes in the vasopressin and serotonin systems can correlate with behavioral alterations, supporting the role of these two neurotransmitters in the regulation of aggression.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=9502824&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAggression
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectCricetinae
dc.subjectFemale
dc.subjectHypothalamus, Anterior
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMesocricetus
dc.subjectPregnancy
dc.subjectSerotonin
dc.subjectSexual Maturation
dc.subject*Social Behavior
dc.subjectVasopressins
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleBehavioral and neurobiological consequences of social subjugation during puberty in golden hamsters
dc.typeArticle
dc.source.journaltitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
dc.source.volume18
dc.source.issue7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2178&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1179
dc.identifier.contextkey770157
refterms.dateFOA2022-08-23T16:34:21Z
html.description.abstract<p>In golden hamsters, offensive aggression is facilitated by vasopressin and inhibited by serotonin. We tested whether these neurotransmitter systems respond to modifications resulting from the stress of threat and attack (i.e., social subjugation) during puberty. Male golden hamsters were weaned at postnatal day 25 (P25), exposed daily to aggressive adults from P28 to P42, and tested for offensive aggression as young adults (P45). The results showed a context-dependent alteration in aggressive behavior. Subjugated animals were more likely to attack younger and weaker intruders than nonsubjugated controls. Conversely, subjugated animals were less likely to attack animals of similar size and age. After testing, the animals were killed, and their brains were collected to determine whether these behavioral changes are underlined by changes in the vasopressin and serotonin systems. Social subjugation resulted in a 50% decrease in vasopressin levels within the anterior hypothalamus, a site involved in the regulation of aggression. Furthermore, whereas the density of vasopressin-immunoreactive fibers within the area was not significantly altered in subjugated animals, the number of serotonin-immunoreactive varicosities within the anterior hypothalamus and lateral septum was 20% higher in subjugated animals than in their controls. These results establish puberty as a developmental period sensitive to environmental stressors. Furthermore, the results show that changes in the vasopressin and serotonin systems can correlate with behavioral alterations, supporting the role of these two neurotransmitters in the regulation of aggression.</p>
dc.identifier.submissionpathoapubs/1179
dc.contributor.departmentNeuropsychiatric Sciences Program, Psychiatry Department
dc.source.pages2667-72


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