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dc.contributor.authorReinhardt, Christopher P.
dc.contributor.authorWeinstein, Howard
dc.contributor.authorMarcel, Robin
dc.contributor.authorLeppo, Jeffrey A.
dc.date2022-08-11T08:09:32.000
dc.date.accessioned2022-08-23T16:34:29Z
dc.date.available2022-08-23T16:34:29Z
dc.date.issued1995-09-01
dc.date.submitted2009-03-10
dc.identifier.citationJ Nucl Med. 1995 Sep;36(9):1645-53.
dc.identifier.issn0161-5505 (Print)
dc.identifier.pmid7658226
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38342
dc.description.abstractRadiolabeled fatty acids such as 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) have unique metabolic properties of potential use as myocardial perfusion tracers. Accordingly, we compared the in vivo pattern of uptake of BMIPP and 201Tl in hypoperfused rabbit myocardium. METHODS: Animals were intubated, ventilated and their arterial pressures monitored. A left thoracotomy was performed. After ligation of a major branch of the circumflex artery, an intravenous injection of BMIPP or BMIPP/201TI was given. Radiolabeled microspheres were used to document the area of risk. After the circulation period, the animals were killed. Tracer deposition within the hearts was determined by either dual-tracer autoradiography (Protocol I) or by segmental tissue analysis (Protocol II). RESULTS: Dual-tracer autoradiographic activity profiles for BMIPP were comparable to those of 201TI. Moreover, the two tracers yielded similar values for normal-to-defect contrast and defect size. The myocardial activity concentration of BMIPP for both protocols correlated strongly with coronary blood flow and compared favorably with 201TI. CONCLUSION: BMIPP and 201TI accurately delineate areas of hypoperfusion distal to a coronary occlusion. Therefore, differences in the myocardial distribution of BMIPP and 201TI in clinical studies may be related to cellular fatty acid metabolism.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=7658226&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://jnm.snmjournals.org/content/36/9/1645.long
dc.subjectAnimals
dc.subjectAutoradiography
dc.subject*Coronary Circulation
dc.subjectDecanoic Acids
dc.subject*Fatty Acids
dc.subjectHeart
dc.subjectIodine Radioisotopes
dc.subjectIodobenzenes
dc.subjectMale
dc.subjectMyocardial Ischemia
dc.subjectMyocardium
dc.subjectRabbits
dc.subjectThallium Radioisotopes
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleComparison of iodine-125-BMIPP and thallium-201 in myocardial hypoperfusion
dc.typeArticle
dc.source.journaltitleJournal of nuclear medicine : official publication, Society of Nuclear Medicine
dc.source.volume36
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1208
dc.identifier.contextkey770186
html.description.abstract<p>Radiolabeled fatty acids such as 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) have unique metabolic properties of potential use as myocardial perfusion tracers. Accordingly, we compared the in vivo pattern of uptake of BMIPP and 201Tl in hypoperfused rabbit myocardium. METHODS: Animals were intubated, ventilated and their arterial pressures monitored. A left thoracotomy was performed. After ligation of a major branch of the circumflex artery, an intravenous injection of BMIPP or BMIPP/201TI was given. Radiolabeled microspheres were used to document the area of risk. After the circulation period, the animals were killed. Tracer deposition within the hearts was determined by either dual-tracer autoradiography (Protocol I) or by segmental tissue analysis (Protocol II). RESULTS: Dual-tracer autoradiographic activity profiles for BMIPP were comparable to those of 201TI. Moreover, the two tracers yielded similar values for normal-to-defect contrast and defect size. The myocardial activity concentration of BMIPP for both protocols correlated strongly with coronary blood flow and compared favorably with 201TI. CONCLUSION: BMIPP and 201TI accurately delineate areas of hypoperfusion distal to a coronary occlusion. Therefore, differences in the myocardial distribution of BMIPP and 201TI in clinical studies may be related to cellular fatty acid metabolism.</p>
dc.identifier.submissionpathoapubs/1208
dc.contributor.departmentDepartment of Radiology, Division of Nuclear Medicine
dc.source.pages1645-53


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