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Myocardial extraction of technetium-99m-[2-(1-methoxybutyl) isonitrile] in the isolated rabbit heart: a myocardial perfusion agent with high extraction and stable retention

dc.contributor.authorDahlberg, Seth T.
dc.contributor.authorMeerdink, Denis J.
dc.contributor.authorGilmore, Madeleine P.
dc.contributor.authorLeppo, Jeffrey A.
dc.date2022-08-11T08:09:32.000
dc.date.accessioned2022-08-23T16:34:30Z
dc.date.available2022-08-23T16:34:30Z
dc.date.issued1993-06-01
dc.date.submitted2009-03-10
dc.identifier.citationJ Nucl Med. 1993 Jun;34(6):927-31.
dc.identifier.issn0161-5505 (Print)
dc.identifier.pmid8509860
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38348
dc.description.abstractTechnetium-99m-[2-(1-methoxybutyl) isonitrile] (MBI) is a potential new compound for the scintigraphic imaging of coronary flow. Evaluation in the blood-perfused isolated rabbit heart model showed this compound to have a myocardial uptake comparable to 201Tl and higher than sestamibi. Although the mean +/- s.d. maximum extraction (Emax) and capillary permeability-surface area product (PScap) of 99mTc-MBI (Emax = 0.45 +/- 0.10, PScap = 1.07 +/- 0.47 ml/min.g) were much less than 201Tl (Emax = 0.71 +/- 0.07, PScap = 2.21 +/- 0.76 ml/min.g, p < 0.0001), the net extraction of 99mTc-MBI (Enet = 0.52 +/- 0.10) was only slightly less than the value for 201Tl (Enet = 0.56 +/- 0.10, p < 0.05). There was no significant difference in the myocardial uptake versus flow between 99mTc-MBI and 201Tl. These data indicate that assessment of relative coronary flow based on the myocardial uptake of 99mTc-MBI should give results comparable to 201Tl. Therefore, 99Tc-MBI may have clinical potential as a radiolabeled myocardial perfusion agent.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8509860&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://jnm.snmjournals.org/content/34/6/927.long
dc.subjectAnimals
dc.subjectCoronary Circulation
dc.subjectHeart
dc.subjectMale
dc.subjectRabbits
dc.subjectTechnetium Tc 99m Sestamibi
dc.subjectThallium Radioisotopes
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleMyocardial extraction of technetium-99m-[2-(1-methoxybutyl) isonitrile] in the isolated rabbit heart: a myocardial perfusion agent with high extraction and stable retention
dc.typeJournal Article
dc.source.journaltitleJournal of nuclear medicine : official publication, Society of Nuclear Medicine
dc.source.volume34
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1213
dc.identifier.contextkey770191
html.description.abstract<p>Technetium-99m-[2-(1-methoxybutyl) isonitrile] (MBI) is a potential new compound for the scintigraphic imaging of coronary flow. Evaluation in the blood-perfused isolated rabbit heart model showed this compound to have a myocardial uptake comparable to 201Tl and higher than sestamibi. Although the mean +/- s.d. maximum extraction (Emax) and capillary permeability-surface area product (PScap) of 99mTc-MBI (Emax = 0.45 +/- 0.10, PScap = 1.07 +/- 0.47 ml/min.g) were much less than 201Tl (Emax = 0.71 +/- 0.07, PScap = 2.21 +/- 0.76 ml/min.g, p < 0.0001), the net extraction of 99mTc-MBI (Enet = 0.52 +/- 0.10) was only slightly less than the value for 201Tl (Enet = 0.56 +/- 0.10, p < 0.05). There was no significant difference in the myocardial uptake versus flow between 99mTc-MBI and 201Tl. These data indicate that assessment of relative coronary flow based on the myocardial uptake of 99mTc-MBI should give results comparable to 201Tl. Therefore, 99Tc-MBI may have clinical potential as a radiolabeled myocardial perfusion agent.</p>
dc.identifier.submissionpathoapubs/1213
dc.contributor.departmentDepartment of Radiology, Division of Nuclear Medicine
dc.source.pages927-31


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