A feedback-controlled dynamic linear actuator to test foot withdrawal thresholds in rat
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UMass Chan Affiliations
Department of PhysiologyDocument Type
Journal ArticlePublication Date
2007-03-21Keywords
Analgesics, Non-NarcoticAnimals
Behavior, Animal
Capsaicin
Feedback
Foot
Functional Laterality
Male
Pain
Pain Measurement
Pain Threshold
Physical Stimulation
Probability
Rats
Rats, Wistar
Reaction Time
Skin
Time Factors
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
We describe a method for evaluating the threshold for cutaneous mechanical sensation in rodents, based on a stimulator that drives a probe against the plantar surface of the foot. The stimulator applies loads that can be either constant or linearly increased. We describe withdrawal responses, including forms of movement that precede foot withdrawals. With constant stimuli, response latency declines in a nonlinear fashion as stimulus magnitude is increased. With ramped stimuli the effect of loading rate is complex, reflecting both the rate of change of the stimulus and the animal's reaction time. We demonstrate the utility of using ramped stimuli in experiments that show that thresholds vary spatially across the foot and experiments that show that intradermal capsaicin injections cause allodynia but not hyperalgesia.Source
J Neurosci Methods. 2007 Jun 15;163(1):44-51. Epub 2007 Feb 16. Link to article on publisher's site
DOI
10.1016/j.jneumeth.2007.02.007Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38438PubMed ID
17368786Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.jneumeth.2007.02.007