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    Hydrophobic sliding: a possible mechanism for drug resistance in human immunodeficiency virus type 1 protease

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    Authors
    Foulkes-Murzycki, Jennifer E.
    Scott, Walter Robert Peter
    Schiffer, Celia A.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2007-02-13
    Keywords
    Amino Acids
    Drug Resistance, Viral
    HIV Protease
    HIV Protease Inhibitors
    Hydrogen Bonding
    Hydrophobicity
    Mutation
    Protein Conformation
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044563/
    Abstract
    Hydrophobic residues outside the active site of HIV-1 protease frequently mutate in patients undergoing protease inhibitor therapy; however, the mechanism by which these mutations confer drug resistance is not understood. From analysis of molecular dynamics simulations, 19 core hydrophobic residues appear to facilitate the conformational changes that occur in HIV-1 protease. The hydrophobic core residues slide by each other, exchanging one hydrophobic van der Waal contact for another, with little energy penalty, while maintaining many structurally important hydrogen bonds. Such hydrophobic sliding may represent a general mechanism by which proteins undergo conformational changes. Mutation of these residues in HIV-1 protease would alter the packing of the hydrophobic core, affecting the conformational flexibility of the protease. Therefore these residues impact the dynamic balance between processing substrates and binding inhibitors, and thus contribute to drug resistance.
    Source

    Structure. 2007 Feb;15(2):225-33. Link to article on publisher's site

    DOI
    10.1016/j.str.2007.01.006
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38492
    PubMed ID
    17292840
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.str.2007.01.006
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    UMass Chan Faculty and Researcher Publications
    Schiffer Lab Publications

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