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    Cytoplasmic polyadenylation in development and beyond

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    Authors
    Richter, Joel D.
    UMass Chan Affiliations
    Department of Molecular Genetics and Microbiology
    Document Type
    Journal Article
    Publication Date
    1999-06-05
    Keywords
    Animals
    Brain
    Caenorhabditis elegans
    Calcium-Calmodulin-Dependent Protein Kinases
    Drosophila
    Long-Term Potentiation
    Mice
    Oocytes
    RNA, Messenger
    Transcription, Genetic
    Visual Cortex
    Xenopus
    Life Sciences
    Medicine and Health Sciences
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    Abstract
    Maternal mRNA translation is regulated in large part by cytoplasmic polyadenylation. This process, which occurs in both vertebrates and invertebrates, is essential for meiosis and body patterning. In spite of the evolutionary conservation of cytoplasmic polyadenylation, many of the cis elements and trans-acting factors appear to have some species specificity. With the recent isolation and cloning of factors involved in both poly(A) elongation and deadenylation, the underlying biochemistry of these reactions is beginning to be elucidated. In addition to early development, cytoplasmic polyadenylation is now known to occur in the adult brain, and there is circumstantial evidence that this process occurs at synapses, where it could mediate the long-lasting phase of long-term potentiation, which is probably the basis of learning and memory. Finally, there may be multiple mechanisms by which polyadenylation promotes translation. Important questions yet to be answered in the field of cytoplasmic polyadenylation are addressed.
    Source
    Microbiol Mol Biol Rev. 1999 Jun;63(2):446-56. Link to article on publisher's website
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38504
    PubMed ID
    10357857
    Related Resources
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    UMass Chan Faculty and Researcher Publications

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