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    RNA interference and mRNA silencing, 2004: how far will they reach

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    Authors
    Pederson, Thoru
    UMass Chan Affiliations
    Program in Cell Dynamics
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2003-12-06
    Keywords
    Animals
    Humans
    *RNA Interference
    RNA Processing, Post-Transcriptional
    RNA, Messenger
    Life Sciences
    Medicine and Health Sciences
    
    Metadata
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    Abstract
    The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.
    Source
    Mol Biol Cell. 2004 Feb;15(2):407-10. Epub 2003 Dec 2. Link to article on publisher's site
    DOI
    10.1091/mbc.E03-10-0726
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38514
    PubMed ID
    14657237
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1091/mbc.E03-10-0726
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    UMass Chan Faculty and Researcher Publications

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