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dc.contributor.authorPederson, Thoru
dc.date2022-08-11T08:09:33.000
dc.date.accessioned2022-08-23T16:35:14Z
dc.date.available2022-08-23T16:35:14Z
dc.date.issued2003-12-06
dc.date.submitted2009-03-24
dc.identifier.citationMol Biol Cell. 2004 Feb;15(2):407-10. Epub 2003 Dec 2. <a href="http://dx.doi.org/10.1091/mbc.E03-10-0726">Link to article on publisher's site</a>
dc.identifier.issn1059-1524 (Print)
dc.identifier.doi10.1091/mbc.E03-10-0726
dc.identifier.pmid14657237
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38514
dc.description.abstractThe discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=14657237&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAnimals
dc.subjectHumans
dc.subject*RNA Interference
dc.subjectRNA Processing, Post-Transcriptional
dc.subjectRNA, Messenger
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleRNA interference and mRNA silencing, 2004: how far will they reach
dc.typeJournal Article
dc.source.journaltitleMolecular biology of the cell
dc.source.volume15
dc.source.issue2
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2386&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1387
dc.identifier.contextkey794884
refterms.dateFOA2022-08-23T16:35:14Z
html.description.abstract<p>The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.</p>
dc.identifier.submissionpathoapubs/1387
dc.contributor.departmentProgram in Cell Dynamics
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.source.pages407-10


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