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The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
1998-10-08Keywords
Amino Acid SequenceAnimals
Carrier Proteins
Cell Division
Cell Nucleolus
Cell Nucleus
Cloning, Molecular
Consensus Sequence
Conserved Sequence
Epidermal Growth FactorGene LibraryGenetic Complementation TestHela CellsHumansMiceMolecular Sequence DataSaccharomyces cerevisiae*Saccharomyces cerevisiae ProteinsSchizosaccharomycesSequence AlignmentSequence Homology, Amino AcidTumor Cells, CulturedZinc FingersLife SciencesMedicine and Health Sciences
Metadata
Show full item recordAbstract
The zinc finger protein ZPR1 translocates from the cytoplasm to the nucleus after treatment of cells with mitogens. The function of nuclear ZPR1 has not been defined. Here we demonstrate that ZPR1 accumulates in the nucleolus of proliferating cells. The role of ZPR1 was examined using a gene disruption strategy. Cells lacking ZPR1 are not viable. Biochemical analysis demonstrated that the loss of ZPR1 caused disruption of nucleolar function, including preribosomal RNA expression. These data establish ZPR1 as an essential protein that is required for normal nucleolar function in proliferating cells.Source
Mol Biol Cell. 1998 Oct;9(10):2963-71.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38533PubMed ID
9763455Related Resources
Link to Article in PubMedCollections
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