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dc.contributor.authorGalcheva-Gargova, Zoya
dc.contributor.authorGangwani, Laxman
dc.contributor.authorKonstantinov, Konstantin N.
dc.contributor.authorMikrut, Monique
dc.contributor.authorTheroux, Steven J.
dc.contributor.authorEnoch, Tamar
dc.contributor.authorDavis, Roger J.
dc.date2022-08-11T08:09:33.000
dc.date.accessioned2022-08-23T16:35:19Z
dc.date.available2022-08-23T16:35:19Z
dc.date.issued1998-10-08
dc.date.submitted2009-03-24
dc.identifier.citationMol Biol Cell. 1998 Oct;9(10):2963-71.
dc.identifier.issn1059-1524 (Print)
dc.identifier.pmid9763455
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38533
dc.description.abstractThe zinc finger protein ZPR1 translocates from the cytoplasm to the nucleus after treatment of cells with mitogens. The function of nuclear ZPR1 has not been defined. Here we demonstrate that ZPR1 accumulates in the nucleolus of proliferating cells. The role of ZPR1 was examined using a gene disruption strategy. Cells lacking ZPR1 are not viable. Biochemical analysis demonstrated that the loss of ZPR1 caused disruption of nucleolar function, including preribosomal RNA expression. These data establish ZPR1 as an essential protein that is required for normal nucleolar function in proliferating cells.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=9763455&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectCarrier Proteins
dc.subjectCell Division
dc.subjectCell Nucleolus
dc.subjectCell Nucleus
dc.subjectCloning, Molecular
dc.subjectConsensus Sequence
dc.subjectConserved Sequence
dc.subjectEpidermal Growth Factor
dc.subjectGene Library
dc.subjectGenetic Complementation Test
dc.subjectHela Cells
dc.subjectHumans
dc.subjectMice
dc.subjectMolecular Sequence Data
dc.subjectSaccharomyces cerevisiae
dc.subject*Saccharomyces cerevisiae Proteins
dc.subjectSchizosaccharomyces
dc.subjectSequence Alignment
dc.subjectSequence Homology, Amino Acid
dc.subjectTumor Cells, Cultured
dc.subjectZinc Fingers
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleThe cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells
dc.typeJournal Article
dc.source.journaltitleMolecular biology of the cell
dc.source.volume9
dc.source.issue10
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2402&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1403
dc.identifier.contextkey794900
refterms.dateFOA2022-08-23T16:35:20Z
html.description.abstract<p>The zinc finger protein ZPR1 translocates from the cytoplasm to the nucleus after treatment of cells with mitogens. The function of nuclear ZPR1 has not been defined. Here we demonstrate that ZPR1 accumulates in the nucleolus of proliferating cells. The role of ZPR1 was examined using a gene disruption strategy. Cells lacking ZPR1 are not viable. Biochemical analysis demonstrated that the loss of ZPR1 caused disruption of nucleolar function, including preribosomal RNA expression. These data establish ZPR1 as an essential protein that is required for normal nucleolar function in proliferating cells.</p>
dc.identifier.submissionpathoapubs/1403
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages2963-71


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