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    Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses

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    Authors
    Luzuriaga, Katherine
    McManus, Margaret M.
    Catalina, Michelle D.
    Mayack, Shane Renee
    Sharkey, Mark E.
    Stevenson, Mario
    Sullivan, John L.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2000-07-11
    Keywords
    Anti-HIV Agents
    CD4 Lymphocyte Count
    Child, Preschool
    Disease Transmission, Vertical
    Drug Therapy, Combination
    HIV Antibodies
    HIV Infections
    HIV-1
    Humans
    Infant
    Infant, Newborn
    Lymphocyte Activation
    RNA, Viral
    Reverse Transcriptase Inhibitors
    T-Lymphocytes, Cytotoxic
    Viral Load
    Virus Replication
    Life Sciences
    Medicine and Health Sciences
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    Abstract
    Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labile extrachromosomal replication intermediates. Despite preservation of immune function, persistent human immunodeficiency type 1 (HIV-1)-specific immune responses were not detected in most infants. The absence of detectable, persisting immune responses in most HIV-1-infected infants treated early contrasts with what is typically seen in adults who are treated early. These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication.
    Source
    J Virol. 2000 Aug;74(15):6984-91.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38679
    PubMed ID
    10888637
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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