Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses
dc.contributor.author | Luzuriaga, Katherine | |
dc.contributor.author | McManus, Margaret M. | |
dc.contributor.author | Catalina, Michelle D. | |
dc.contributor.author | Mayack, Shane Renee | |
dc.contributor.author | Sharkey, Mark E. | |
dc.contributor.author | Stevenson, Mario | |
dc.contributor.author | Sullivan, John L. | |
dc.date | 2022-08-11T08:09:34.000 | |
dc.date.accessioned | 2022-08-23T16:35:58Z | |
dc.date.available | 2022-08-23T16:35:58Z | |
dc.date.issued | 2000-07-11 | |
dc.date.submitted | 2009-03-26 | |
dc.identifier.citation | J Virol. 2000 Aug;74(15):6984-91. | |
dc.identifier.issn | 0022-538X (Print) | |
dc.identifier.pmid | 10888637 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/38679 | |
dc.description.abstract | Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labile extrachromosomal replication intermediates. Despite preservation of immune function, persistent human immunodeficiency type 1 (HIV-1)-specific immune responses were not detected in most infants. The absence of detectable, persisting immune responses in most HIV-1-infected infants treated early contrasts with what is typically seen in adults who are treated early. These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10888637&dopt=Abstract">Link to Article in PubMed</a> | |
dc.subject | Anti-HIV Agents | |
dc.subject | CD4 Lymphocyte Count | |
dc.subject | Child, Preschool | |
dc.subject | Disease Transmission, Vertical | |
dc.subject | Drug Therapy, Combination | |
dc.subject | HIV Antibodies | |
dc.subject | HIV Infections | |
dc.subject | HIV-1 | |
dc.subject | Humans | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Lymphocyte Activation | |
dc.subject | RNA, Viral | |
dc.subject | Reverse Transcriptase Inhibitors | |
dc.subject | T-Lymphocytes, Cytotoxic | |
dc.subject | Viral Load | |
dc.subject | Virus Replication | |
dc.subject | Life Sciences | |
dc.subject | Medicine and Health Sciences | |
dc.title | Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses | |
dc.type | Journal Article | |
dc.source.journaltitle | Journal of virology | |
dc.source.volume | 74 | |
dc.source.issue | 15 | |
dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2534&context=oapubs&unstamped=1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/1535 | |
dc.identifier.contextkey | 798511 | |
refterms.dateFOA | 2022-08-23T16:35:58Z | |
html.description.abstract | <p>Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labile extrachromosomal replication intermediates. Despite preservation of immune function, persistent human immunodeficiency type 1 (HIV-1)-specific immune responses were not detected in most infants. The absence of detectable, persisting immune responses in most HIV-1-infected infants treated early contrasts with what is typically seen in adults who are treated early. These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication.</p> | |
dc.identifier.submissionpath | oapubs/1535 | |
dc.contributor.department | Program in Molecular Medicine | |
dc.contributor.department | Department of Pediatrics | |
dc.source.pages | 6984-91 |