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    Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans

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    Authors
    Demkowicz, Walter E.
    Ennis, Francis A.
    UMass Chan Affiliations
    Center for Infectious Disease and Vaccine Research
    Department of Medicine
    Document Type
    Journal Article
    Publication Date
    1993-03-01
    Keywords
    Antibodies, Monoclonal
    Antigens, CD8
    Cells, Cultured
    Clone Cells
    Cytotoxicity, Immunologic
    HLA Antigens
    Humans
    *Immunity, Cellular
    Immunologic Memory
    Lymphocyte Activation
    Phenotype
    T-Lymphocytes, Cytotoxic
    Vaccinia virus
    Life Sciences
    Medicine and Health Sciences
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    Abstract
    Stimulation of human vaccinia virus immune peripheral blood mononuclear cells in vitro from vaccinia virus-immune donors with live vaccinia virus-infected autologous cells generated vaccinia virus-specific cytotoxic T lymphocytes (CTL) capable of lysing vaccinia virus-infected cells. We generated vaccinia virus-specific CD8+ clones and CD4+ CTL lines by limiting dilution from two donors by using peripheral blood mononuclear cells obtained 2 months or 4 years postrevaccination with vaccinia virus. These results demonstrate that vaccinia virus-specific CTL are generated as a result of immunization of humans with vaccinia virus and that both CD8(+)- and CD4(+)-specific T cells are maintained as memory cells.
    Source
    J Virol. 1993 Mar;67(3):1538-44.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38705
    PubMed ID
    8437229
    Related Resources
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    UMass Chan Faculty and Researcher Publications

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