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Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans

dc.contributor.authorDemkowicz, Walter E.
dc.contributor.authorEnnis, Francis A.
dc.date2022-08-11T08:09:34.000
dc.date.accessioned2022-08-23T16:36:04Z
dc.date.available2022-08-23T16:36:04Z
dc.date.issued1993-03-01
dc.date.submitted2009-03-26
dc.identifier.citationJ Virol. 1993 Mar;67(3):1538-44.
dc.identifier.issn0022-538X (Print)
dc.identifier.pmid8437229
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38705
dc.description.abstractStimulation of human vaccinia virus immune peripheral blood mononuclear cells in vitro from vaccinia virus-immune donors with live vaccinia virus-infected autologous cells generated vaccinia virus-specific cytotoxic T lymphocytes (CTL) capable of lysing vaccinia virus-infected cells. We generated vaccinia virus-specific CD8+ clones and CD4+ CTL lines by limiting dilution from two donors by using peripheral blood mononuclear cells obtained 2 months or 4 years postrevaccination with vaccinia virus. These results demonstrate that vaccinia virus-specific CTL are generated as a result of immunization of humans with vaccinia virus and that both CD8(+)- and CD4(+)-specific T cells are maintained as memory cells.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8437229&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAntibodies, Monoclonal
dc.subjectAntigens, CD8
dc.subjectCells, Cultured
dc.subjectClone Cells
dc.subjectCytotoxicity, Immunologic
dc.subjectHLA Antigens
dc.subjectHumans
dc.subject*Immunity, Cellular
dc.subjectImmunologic Memory
dc.subjectLymphocyte Activation
dc.subjectPhenotype
dc.subjectT-Lymphocytes, Cytotoxic
dc.subjectVaccinia virus
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleVaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans
dc.typeJournal Article
dc.source.journaltitleJournal of virology
dc.source.volume67
dc.source.issue3
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2558&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1559
dc.identifier.contextkey798536
refterms.dateFOA2022-08-23T16:36:04Z
html.description.abstract<p>Stimulation of human vaccinia virus immune peripheral blood mononuclear cells in vitro from vaccinia virus-immune donors with live vaccinia virus-infected autologous cells generated vaccinia virus-specific cytotoxic T lymphocytes (CTL) capable of lysing vaccinia virus-infected cells. We generated vaccinia virus-specific CD8+ clones and CD4+ CTL lines by limiting dilution from two donors by using peripheral blood mononuclear cells obtained 2 months or 4 years postrevaccination with vaccinia virus. These results demonstrate that vaccinia virus-specific CTL are generated as a result of immunization of humans with vaccinia virus and that both CD8(+)- and CD4(+)-specific T cells are maintained as memory cells.</p>
dc.identifier.submissionpathoapubs/1559
dc.contributor.departmentCenter for Infectious Disease and Vaccine Research
dc.contributor.departmentDepartment of Medicine
dc.source.pages1538-44


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