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Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri

dc.contributor.authorGeck, Peter
dc.contributor.authorWhitaker, Scott A.
dc.contributor.authorMedveczky, Maria M.
dc.contributor.authorMedveczky, Peter G.
dc.date2022-08-11T08:09:34.000
dc.date.accessioned2022-08-23T16:36:10Z
dc.date.available2022-08-23T16:36:10Z
dc.date.issued1990-07-01
dc.date.submitted2009-03-26
dc.identifier.citationJ Virol. 1990 Jul;64(7):3509-15.
dc.identifier.issn0022-538X (Print)
dc.identifier.pmid2161952
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38727
dc.description.abstractSequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=2161952&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectBase Sequence
dc.subjectBlotting, Northern
dc.subjectBlotting, Southern
dc.subjectCloning, Molecular
dc.subjectCollagen
dc.subjectDNA, Viral
dc.subjectGene Expression
dc.subject*Genes, Viral
dc.subjectHerpesvirus 2, Saimiriine
dc.subjectMolecular Sequence Data
dc.subjectRNA, Messenger
dc.subjectRestriction Mapping
dc.subjectSequence Homology, Nucleic Acid
dc.subjectViral Structural Proteins
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleExpression of collagenlike sequences by a tumor virus, herpesvirus saimiri
dc.typeJournal Article
dc.source.journaltitleJournal of virology
dc.source.volume64
dc.source.issue7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2578&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1579
dc.identifier.contextkey798557
refterms.dateFOA2022-08-23T16:36:10Z
html.description.abstract<p>Sequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.</p>
dc.identifier.submissionpathoapubs/1579
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.contributor.departmentDepartment of Pharmacology
dc.source.pages3509-15


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