Breast specimen microcalcifications: radiographic validation and pathologic-radiologic correlation
UMass Chan Affiliations
Department of RadiologyDocument Type
Journal ArticlePublication Date
1991-08-01Keywords
BreastBreast Neoplasms
Calcinosis
Carcinoma
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Papillary
Diagnosis, Differential
*Histological Techniques
Humans
*Mammography
Microtomy
Prospective Studies
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
A prospective analysis of specimens from location and biopsy of mammographically suspect microcalcifications in 108 patients was carried out to determine if microcalcifications were lost during histopathologic processing and the clinical relevance of such loss. Nine hundred sixty-eight paraffin blocks were prepared from 425 gross tissue slices containing calcifications identified at radiography of the specimens. Calcium was apparently lost both during preparation of the blocks (13.6%) and after slide preparation (12.6%), for a total possible loss of 26.2%. All specimens demonstrated calcification histologically. One pathology report was amended because of information obtained after recuts, but all cancers were detected on original slides whether or not calcifications were identified initially. The results indicate that, by following the suggestions offered to ensure adequate histopathologic sampling of calcification seen at mammography, most if not all of the calcification present can be detected on the original slide.Source
Radiology. 1991 Aug;180(2):397-401.
DOI
10.1148/radiology.180.2.1648756Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38756PubMed ID
1648756Related Resources
ae974a485f413a2113503eed53cd6c53
10.1148/radiology.180.2.1648756