Show simple item record

dc.contributor.authorCandilis, Philip J.
dc.contributor.authorGeppert, Cynthia M. A.
dc.contributor.authorFletcher, Kenneth E.
dc.contributor.authorLidz, Charles W.
dc.contributor.authorAppelbaum, Paul S.
dc.date2022-08-11T08:09:35.000
dc.date.accessioned2022-08-23T16:36:25Z
dc.date.available2022-08-23T16:36:25Z
dc.date.issued2005-10-29
dc.date.submitted2009-03-31
dc.identifier.citation<p>Schizophr Bull. 2006 Jan;32(1):159-65. Epub 2005 Oct 27. <a href="http://dx.doi.org/10.1093/schbul/sbj016">Link to article on publisher's site</a></p>
dc.identifier.issn0586-7614 (Print)
dc.identifier.doi10.1093/schbul/sbj016
dc.identifier.pmid16254062
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38783
dc.description.abstractGreater attention is being focused on the willingness and motivations of potential subjects who are recruited for research protocols. Given the importance of subjects' abilities to choose freely and reason through their decisions about entering psychiatric research, empirical researchers have been developing assessment and education tools that address the potential vulnerabilities of research subjects. In this study subjects' responses and reasons for or against participation were elicited as part of an assessment of their research decision making. Fifty-two persons diagnosed with a thought disorder were asked to consider a hypothetical research study using the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR). Their responses were documented, coded for content, and correlated with demographic characteristics and scores on scales rating psychosis, cognition, and health-related quality of life. Subjects expressed common considerations that have been identified by other psychiatric investigators, as well as by those studying nonpsychiatric protocols. In general, reasons were both appropriate to the study being considered and appropriately linked to common considerations that flowed logically from the study. However, elements of the therapeutic misconception were evident as well. Willingness to participate was correlated with higher MacCAT-CR scores on certain scales, better education, and lower levels of psychosis and cognitive impairment. These findings highlight both the strengths and weaknesses of the decision making of research subjects with thought disorder. Research protections and assessments may consequently be appropriately targeted to specific vulnerabilities. Because of differences in severity of illness, cognition, and reasoning among subjects who decline to participate in research, greater attention to this population appears warranted.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16254062&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632177/
dc.subjectAdult
dc.subjectBiomedical Research
dc.subjectCognition Disorders
dc.subjectDemography
dc.subjectFemale
dc.subject*Human Experimentation
dc.subjectHumans
dc.subjectMale
dc.subjectSchizophrenia
dc.subject*Thinking
dc.subject*Volition
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleWillingness of subjects with thought disorder to participate in research
dc.typeJournal Article
dc.source.journaltitleSchizophrenia bulletin
dc.source.volume32
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1629
dc.identifier.contextkey805450
html.description.abstract<p>Greater attention is being focused on the willingness and motivations of potential subjects who are recruited for research protocols. Given the importance of subjects' abilities to choose freely and reason through their decisions about entering psychiatric research, empirical researchers have been developing assessment and education tools that address the potential vulnerabilities of research subjects. In this study subjects' responses and reasons for or against participation were elicited as part of an assessment of their research decision making. Fifty-two persons diagnosed with a thought disorder were asked to consider a hypothetical research study using the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR). Their responses were documented, coded for content, and correlated with demographic characteristics and scores on scales rating psychosis, cognition, and health-related quality of life. Subjects expressed common considerations that have been identified by other psychiatric investigators, as well as by those studying nonpsychiatric protocols. In general, reasons were both appropriate to the study being considered and appropriately linked to common considerations that flowed logically from the study. However, elements of the therapeutic misconception were evident as well. Willingness to participate was correlated with higher MacCAT-CR scores on certain scales, better education, and lower levels of psychosis and cognitive impairment. These findings highlight both the strengths and weaknesses of the decision making of research subjects with thought disorder. Research protections and assessments may consequently be appropriately targeted to specific vulnerabilities. Because of differences in severity of illness, cognition, and reasoning among subjects who decline to participate in research, greater attention to this population appears warranted.</p>
dc.identifier.submissionpathoapubs/1629
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages159-65


This item appears in the following Collection(s)

Show simple item record