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    Controlling gene expression in living cells through small molecule-RNA interactions

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    Authors
    Werstuck, Geoffrey
    Green, Michael R.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    1998-10-09
    Keywords
    Animals
    Anti-Bacterial Agents
    Base Sequence
    Benzimidazoles
    Bisbenzimide
    CHO Cells
    Cricetinae
    Drug Resistance, Microbial
    Escherichia coli
    *Gene Expression Regulation
    Kanamycin
    Ligands
    Molecular Sequence Data
    Protein Biosynthesis
    RNA
    RNA, Messenger
    Tobramycin
    Transfection
    Life Sciences
    Medicine and Health Sciences
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    Link to Full Text
    http://dx.doi.org/10.1126/science.282.5387.296
    Abstract
    Short RNA aptamers that specifically bind to a wide variety of ligands in vitro can be isolated from randomized pools of RNA. Here it is shown that small molecule aptamers also bound their ligand in vivo, enabling development of a method for controlling gene expression in living cells. Insertion of a small molecule aptamer into the 5' untranslated region of a messenger RNA allowed its translation to be repressible by ligand addition in vitro as well as in mammalian cells. The ability of small molecules to control expression of specific genes could facilitate studies in many areas of biology and medicine.
    Source

    Science. 1998 Oct 9;282(5387):296-8.

    DOI
    10.1126/science.282.5387.296
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38799
    PubMed ID
    9765156
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1126/science.282.5387.296
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