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dc.contributor.authorStevenson, Mario
dc.date2022-08-11T08:09:35.000
dc.date.accessioned2022-08-23T16:36:40Z
dc.date.available2022-08-23T16:36:40Z
dc.date.issued2004-04-28
dc.date.submitted2009-03-31
dc.identifier.citation<p>Top HIV Med. 2004 Mar-Apr;12(1):4-7.</p>
dc.identifier.issn1542-8826 (Print)
dc.identifier.pmid15111726
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38838
dc.description.abstractAs with last year's meeting, perhaps the greatest emphasis in the basic science categories was in the area of cellular cofactors that influence HIV-1 replication either positively or negatively. A number of presentations provided detailed insight into the mechanism by which APOBEC 3G, the cellular target of Vif, effects its antiviral activity. The surprising thing is that this antiviral activity is not restricted to primate lentiviruses but is active against retroviruses and even hepatitis viruses. In the area of positive-acting cellular cofactors, the emphasis was on those cellular proteins that facilitate egress of the virus from the infected cell. It is now apparent that viruses such as HIV-1 can bud into cytoplasmic vesicles in order to establish a unique intracellular reservoir. How viruses move between cells was also the focus of several presentations at the meeting, and there were further surprises about the mechanism by which HIV-1 may establish latent infection.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15111726&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://www.iasusa.org/sites/default/files/tam/12-1-4.pdf
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectResearch
dc.subjectVirus Replication
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleDevelopments in basic science research. Highlights of the 11th Conference on Retroviruses and Opportunistic Infections, February 8-11, 2004, San Francisco, California, USA
dc.typeJournal Article
dc.source.journaltitleTopics in HIV medicine : a publication of the International AIDS Society, USA
dc.source.volume12
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1679
dc.identifier.contextkey805500
html.description.abstract<p>As with last year's meeting, perhaps the greatest emphasis in the basic science categories was in the area of cellular cofactors that influence HIV-1 replication either positively or negatively. A number of presentations provided detailed insight into the mechanism by which APOBEC 3G, the cellular target of Vif, effects its antiviral activity. The surprising thing is that this antiviral activity is not restricted to primate lentiviruses but is active against retroviruses and even hepatitis viruses. In the area of positive-acting cellular cofactors, the emphasis was on those cellular proteins that facilitate egress of the virus from the infected cell. It is now apparent that viruses such as HIV-1 can bud into cytoplasmic vesicles in order to establish a unique intracellular reservoir. How viruses move between cells was also the focus of several presentations at the meeting, and there were further surprises about the mechanism by which HIV-1 may establish latent infection.</p>
dc.identifier.submissionpathoapubs/1679
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages4-7


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