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The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
1993-06-25Keywords
Activating Transcription FactorsAnimals
Binding Sites
Blood Proteins
Cell Line
Cyclic AMP Response Element-Binding
Protein
DNA
Fungal Proteins
Gene ExpressionHaplorhiniMacromolecular SubstancesPlasmidsProtein KinasesRecombinant Fusion Proteins*Saccharomyces cerevisiae ProteinsTranscription FactorsTranscription, GeneticLife SciencesMedicine and Health Sciences
Metadata
Show full item recordAbstract
Cyclic AMP response element binding protein (CREB) activates transcription of cAMP response element (CRE)-containing promoters following an elevation of intracellular cAMP. Here we show that CREB and the highly related protein ATF-1 are also potent transcription inhibitors. Strikingly, CREB inhibits transcription of multiple activators, whose DNA-binding domains and activation regions are unrelated to one another. Inhibition requires that the CREB dimerization and DNA-binding domains are intact. However, inhibition is not dependent upon the presence of a CRE in the promoter, and does not involve heterodimer formation between CREB and the activator. The ability of an activator protein to inhibit transcription in such a promiscuous fashion has not been previously reported.Source
Nucleic Acids Res. 1993 Jun 25;21(12):2907-11.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/38871PubMed ID
8332500Related Resources
Link to Article in PubMedCollections
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