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Inhibition of DNA polymerase alpha by aphidicolin derivatives

dc.contributor.authorArabshahi, Lili
dc.contributor.authorBrown, Neal C.
dc.contributor.authorKhan, Naseema N.
dc.contributor.authorWright, George E.
dc.date2022-08-11T08:09:36.000
dc.date.accessioned2022-08-23T16:36:51Z
dc.date.available2022-08-23T16:36:51Z
dc.date.issued1988-06-10
dc.date.submitted2009-04-02
dc.identifier.citationNucleic Acids Res. 1988 Jun 10;16(11):5107-13.
dc.identifier.issn0305-1048 (Print)
dc.identifier.pmid3133639
dc.identifier.urihttp://hdl.handle.net/20.500.14038/38879
dc.description.abstract17-Acetylaphidicolin was 10-fold weaker and two derivatives lacking hydroxyl groups at the 16 and 17 positions were 100-fold weaker than aphidicolin as inhibitors of DNA polymerase alpha from HeLa and Chinese hamster ovary cells. 17,18-Diacetyl, 3,17,18-triacetyl and 3-epi derivatives of aphidicolin were inactive. Active compounds were, like aphidicolin, competitive with dCTP and did not inhibit aphidicolin-resistant DNA polymerases.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=3133639&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAnimals
dc.subjectAphidicolin
dc.subjectCricetinae
dc.subjectCricetulus
dc.subjectDNA Polymerase II
dc.subjectDeoxycytosine Nucleotides
dc.subjectDiterpenes
dc.subjectFemale
dc.subjectFibroblasts
dc.subjectHela Cells
dc.subjectOvary
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleInhibition of DNA polymerase alpha by aphidicolin derivatives
dc.typeJournal Article
dc.source.journaltitleNucleic acids research
dc.source.volume16
dc.source.issue11
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2714&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/1715
dc.identifier.contextkey808478
refterms.dateFOA2022-08-23T16:36:51Z
html.description.abstract<p>17-Acetylaphidicolin was 10-fold weaker and two derivatives lacking hydroxyl groups at the 16 and 17 positions were 100-fold weaker than aphidicolin as inhibitors of DNA polymerase alpha from HeLa and Chinese hamster ovary cells. 17,18-Diacetyl, 3,17,18-triacetyl and 3-epi derivatives of aphidicolin were inactive. Active compounds were, like aphidicolin, competitive with dCTP and did not inhibit aphidicolin-resistant DNA polymerases.</p>
dc.identifier.submissionpathoapubs/1715
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.source.pages5107-13


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