Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease
King, Nancy M.
Nalivaika, Ellen A.
Schiffer, Celia A.
UMass Chan AffiliationsDepartment of Biochemistry and Molecular Pharmacology
Document TypeJournal Article
Drug Resistance, Viral
HIV Protease Inhibitors
Chemical and Pharmacologic Phenomena
Medical Molecular Biology
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AbstractIn our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.
SourceAntimicrob Agents Chemother. 2006 Apr;50(4):1518-21. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/38982
Related ResourcesLink to article in PubMed