Authors
Altieri, Dario C.UMass Chan Affiliations
Department of Cancer Biology and the Cancer CenterDocument Type
Journal ArticlePublication Date
2008-10-22Keywords
HumansMicrotubule-Associated Proteins
Neoplasm Proteins
Neoplasms
Signal Transduction
Subcellular Fractions
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
A little over 10 years after its discovery in 1997, the small inhibitor of apoptosis (IAP) protein, survivin, continues to generate intense interest and keen attention from disparate segments of basic and disease-related research. Part of this interest reflects the intricate biology of this multifunctional protein that intersects fundamental networks of cellular homeostasis. Part is because of the role of survivin as a cancer gene, which touches nearly every aspect of the disease, from onset to outcome. And part is due to the potential value of survivin for novel cancer diagnostics and therapeutics, which have already reached the clinic, and with some promise. Grappling with emerging new signaling circuits in survivin biology, and their implications in cancer, will further our understanding of this nodal protein, and open fresh opportunities for translational oncology research.Source
Oncogene. 2008 Oct 20;27(48):6276-84. Link to article on publisher's site
DOI
10.1038/onc.2008.303Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39083PubMed ID
18931693Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/onc.2008.303