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    In vitro activity of loracarbef (LY163892), a new oral carbacephem antimicrobial agent, against respiratory isolates of Haemophilus influenzae and Moraxella catarrhalis

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    Authors
    Doern, Gary V.
    Vautour, Raymond
    Parker, Douglas
    Tubert, Tracy A.
    Torres, Brenda B.
    UMass Chan Affiliations
    Department of Clinical Microbiology
    Document Type
    Journal Article
    Publication Date
    1991-07-01
    Keywords
    Anti-Bacterial Agents
    Bacterial Infections
    Cephalosporins
    Haemophilus Infections
    Haemophilus influenzae
    Humans
    Microbial Sensitivity Tests
    Moraxella (Branhamella) catarrhalis
    Respiratory Tract Infections
    beta-Lactamases
    Medical Microbiology
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    Abstract
    The in vitro activity of a new orally administered carbacephem analog of cefaclor, loracarbef (LY163892), was compared with those of cefaclor and several other oral antimicrobial agents against recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis. Loracarbef was found to be slightly more active than cefaclor against H. influenzae and had activity essentially equivalent to that of cefaclor for M. catarrhalis. Resistance to loracarbef was uncommon and was noted only with rare beta-lactamase-producing strains of H. influenzae. On the basis of these observations, loracarbef may be of utility in the management of localized, non-life-threatening infections caused by H. influenzae and M. catarrhalis.
    Source
    Antimicrob Agents Chemother. 1991 Jul;35(7):1504-7.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/39092
    PubMed ID
    1929318
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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