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    RNA target specificity of the embryonic cell fate determinant POS-1

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    Authors
    Farley, Brian M.
    Pagano, John M.
    Ryder, Sean P.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2008-10-28
    Keywords
    Animals
    Base Sequence
    Binding Sites
    Caenorhabditis elegans
    Caenorhabditis elegans Proteins
    Carrier Proteins
    Consensus Sequence
    Embryonic Development
    RNA, Messenger
    RNA-Binding Proteins
    Untranslated Regions
    Life Sciences
    Medicine and Health Sciences
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590972/
    Abstract
    Specification of Caenorhabditis elegans body axes and cell fates occurs prior to the activation of zygotic transcription. Several CCCH-type tandem zinc finger (TZF) proteins coordinate local activation of quiescent maternal mRNAs after fertilization, leading to asymmetric expression of factors required for patterning. The primary determinant of posterior fate is the TZF protein POS-1. Mutants of pos-1 are maternal effect lethal with a terminal phenotype that includes excess pharyngeal tissue and no endoderm or germline. Here, we delineate the consensus POS-1 recognition element (PRE) required for specific recognition of its target mRNAs. The PRE is necessary but not sufficient to pattern the expression of a reporter. The PRE is distinct from sequences recognized by related proteins from both mammals and nematodes, demonstrating that variants of this protein family can recognize divergent RNA sequences. The PRE is found within the 3' untranslated region of 227 maternal transcripts required for early development, including genes involved in endoderm and germline specification. The results enable prediction of novel targets that explain the pleiotropy of the pos-1 phenotype.
    Source

    RNA. 2008 Dec;14(12):2685-97. Epub 2008 Oct 24. Link to article on publisher's site

    DOI
    10.1261/rna.1256708
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/39113
    PubMed ID
    18952820
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1261/rna.1256708
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