Paramyxoviruses: different receptors - different mechanisms of fusion
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyDocument Type
Journal ArticlePublication Date
2008-03-19Keywords
AnimalsBinding Sites
HN Protein
Hemagglutinins, Viral
Humans
Measles virus
*Membrane Fusion
Newcastle disease virus
Receptors, Virus
Viral Proteins
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.Source
Trends Microbiol. 2008 Apr;16(4):135-7. Epub 2008 Mar 17. Link to article on publisher's site
DOI
10.1016/j.tim.2008.01.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39137PubMed ID
18346895Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.tim.2008.01.006