Paramyxoviruses: different receptors - different mechanisms of fusion
UMass Chan AffiliationsDepartment of Molecular Genetics and Microbiology
Newcastle disease virus
Medicine and Health Sciences
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AbstractParamyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.
Trends Microbiol. 2008 Apr;16(4):135-7. Epub 2008 Mar 17. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/39137