UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2008-07-26Keywords
AdipocytesAdipose Tissue, White
Animals
Cells, Cultured
Energy Metabolism
Fatty Acids, Nonesterified
Lipolysis
Mice
Mice, Knockout
Mitochondria
Models, Biological
Oxidation-Reduction
Proteins
Up-Regulation
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Fat-specific protein of 27 kDa (FSP27) is a highly expressed adipocyte protein that promotes triglyceride accumulation within lipid droplets. In this issue of the JCI, Nishino et al. show that FSP27 also helps to maintain the characteristically large unilocular lipid droplet structure within each white adipocyte (see the related article beginning on page 2808). Fragmentation of lipid droplets in white adipocytes from FSP27-KO mice caused both increased lipolysis and upregulation of genes enhancing mitochondrial oxidative metabolism. This increased energy expenditure in turn protected the mice from diet-induced obesity and insulin resistance. These new results highlight powerful mechanisms that tightly coordinate rates of triglyceride storage in lipid droplets with mitochondrial fatty acid oxidation in white adipocytes.Source
J Clin Invest. 2008 Aug;118(8):2693-6. Link to article on publisher's siteDOI
10.1172/JCI36554Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39208PubMed ID
18654644Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1172/JCI36554