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dc.contributor.authorSchneider, Kristin L.
dc.contributor.authorBodenlos, Jamie S.
dc.contributor.authorMa, Yunsheng
dc.contributor.authorOlendzki, Barbara C.
dc.contributor.authorOleski, Jessica
dc.contributor.authorMerriam, Philip A.
dc.contributor.authorCrawford, Sybil L.
dc.contributor.authorOckene, Ira S.
dc.contributor.authorPagoto, Sherry L.
dc.date2022-08-11T08:09:38.000
dc.date.accessioned2022-08-23T16:38:19Z
dc.date.available2022-08-23T16:38:19Z
dc.date.issued2008-09-17
dc.date.submitted2009-11-13
dc.identifier.citationBMC Psychiatry. 2008 Sep 15;8:77. <a href="http://dx.doi.org/10.1186/1471-244X-8-77">Link to article on publisher's site</a>
dc.identifier.issn1471-244X (Electronic)
dc.identifier.doi10.1186/1471-244X-8-77
dc.identifier.pmid18793398
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39221
dc.description.abstractBACKGROUND: Obesity is often comorbid with depression and individuals with this comorbidity fare worse in behavioral weight loss treatment. Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial. METHODS AND DESIGN: This randomized clinical trial will examine whether behavior therapy for depression administered prior to standard weight loss treatment produces greater weight loss than standard weight loss treatment alone. Obese women with major depressive disorder (N = 174) will be recruited from primary care clinics and the community and randomly assigned to one of the two treatment conditions. Treatment will last 2 years, and will include a 6-month intensive treatment phase followed by an 18-month maintenance phase. Follow-up assessment will occur at 6-months and 1- and 2 years following randomization. The primary outcome is weight loss. The study was designed to provide 90% power for detecting a weight change difference between conditions of 3.1 kg (standard deviation of 5.5 kg) at 1-year assuming a 25% rate of loss to follow-up. Secondary outcomes include depression, physical activity, dietary intake, psychosocial variables and cardiovascular risk factors. Potential mediators (e.g., adherence, depression, physical activity and caloric intake) of the intervention effect on weight change will also be examined. DISCUSSION: Treating depression before administering intensive health behavior interventions could potentially boost the impact on both mental and physical health outcomes. TRIAL REGISTRATION: NCT00572520.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18793398&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAdult
dc.subjectAged
dc.subject*Behavior Therapy
dc.subjectComorbidity
dc.subjectDepressive Disorder, Major
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectResearch Design
dc.subjectYoung Adult
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleDesign and methods for a randomized clinical trial treating comorbid obesity and major depressive disorder
dc.typeJournal Article
dc.source.journaltitleBMC psychiatry
dc.source.volume8
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3026&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2027
dc.identifier.contextkey1063410
refterms.dateFOA2022-08-23T16:38:19Z
html.description.abstract<p>BACKGROUND: Obesity is often comorbid with depression and individuals with this comorbidity fare worse in behavioral weight loss treatment. Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial. METHODS AND DESIGN: This randomized clinical trial will examine whether behavior therapy for depression administered prior to standard weight loss treatment produces greater weight loss than standard weight loss treatment alone. Obese women with major depressive disorder (N = 174) will be recruited from primary care clinics and the community and randomly assigned to one of the two treatment conditions. Treatment will last 2 years, and will include a 6-month intensive treatment phase followed by an 18-month maintenance phase. Follow-up assessment will occur at 6-months and 1- and 2 years following randomization. The primary outcome is weight loss. The study was designed to provide 90% power for detecting a weight change difference between conditions of 3.1 kg (standard deviation of 5.5 kg) at 1-year assuming a 25% rate of loss to follow-up. Secondary outcomes include depression, physical activity, dietary intake, psychosocial variables and cardiovascular risk factors. Potential mediators (e.g., adherence, depression, physical activity and caloric intake) of the intervention effect on weight change will also be examined. DISCUSSION: Treating depression before administering intensive health behavior interventions could potentially boost the impact on both mental and physical health outcomes. TRIAL REGISTRATION: NCT00572520.</p>
dc.identifier.submissionpathoapubs/2027
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages77


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