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dc.contributor.authorSoller, Babs R.
dc.contributor.authorYang, Ye
dc.contributor.authorSoyemi, Olusola O.
dc.contributor.authorRyan, Kathy L.
dc.contributor.authorRickards, Caroline A.
dc.contributor.authorWalz, J. Matthias
dc.contributor.authorHeard, Stephen O.
dc.contributor.authorConvertino, Victor A.
dc.date2022-08-11T08:09:38.000
dc.date.accessioned2022-08-23T16:38:21Z
dc.date.available2022-08-23T16:38:21Z
dc.date.issued2008-02-01
dc.date.submitted2009-11-13
dc.identifier.citation<p>J Appl Physiol. 2008 Feb;104(2):475-81. Epub 2007 Nov 15. <a href="http://dx.doi.org/10.1152/japplphysiol.00600.2007">Link to article on publisher's site</a></p>
dc.identifier.issn8750-7587 (Print)
dc.identifier.doi10.1152/japplphysiol.00600.2007
dc.identifier.pmid18006869
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39230
dc.description.abstractTen healthy human volunteers were subjected to progressive lower body negative pressure (LBNP) to the onset of cardiovascular collapse to compare the response of noninvasively determined skin and fat corrected deep muscle oxygen saturation (SmO2) and pH to standard hemodynamic parameters for early detection of imminent hemodynamic instability. Muscle SmO2 and pH were determined with a novel near infrared spectroscopic (NIRS) technique. Heart rate (HR) was measured continuously via ECG, and arterial blood pressure (BP) and stroke volume (SV) were obtained noninvasively via Finometer and impedance cardiography on a beat-to-beat basis. SmO2 and SV were significantly decreased during the first LBNP level (-15 mmHg), whereas HR and BP were late indicators of impending cardiovascular collapse. SmO2 declined in parallel with SV and inversely with total peripheral resistance, suggesting, in this model, that SmO2 is an early indicator of a reduction in oxygen delivery through vasoconstriction. Muscle pH decreased later, suggesting an imbalance between delivery and demand. Spectroscopic determination of SmO2 is noninvasive and continuous, providing an early indication of impending cardiovascular collapse resulting from progressive reduction in central blood volume.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18006869&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1152/japplphysiol.00600.2007
dc.subjectAdipose Tissue
dc.subjectAdult
dc.subjectBlood Pressure
dc.subjectBlood Volume
dc.subjectElectrocardiography
dc.subjectFemale
dc.subjectHeart Rate
dc.subject*Hemodynamics
dc.subjectHumans
dc.subjectHydrogen-Ion Concentration
dc.subjectHypovolemia
dc.subjectLower Body Negative Pressure
dc.subjectMale
dc.subjectModels, Cardiovascular
dc.subjectMuscle, Skeletal
dc.subjectOxygen
dc.subject*Oxygen Consumption
dc.subjectSkin
dc.subject*Spectrophotometry, Infrared
dc.subjectStroke Volume
dc.subjectTime Factors
dc.subjectVascular Resistance
dc.subjecttissue oxygen
dc.subjectnear infrared spectroscopy
dc.subjectphysiological monitoring
dc.subjecthemodynamic instability
dc.subjectlower body negative pressure
dc.subjectAnesthesiology
dc.subjectCardiovascular System
dc.subjectDiagnosis
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectOther Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectPhysiology
dc.titleNoninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans
dc.typeJournal Article
dc.source.journaltitleJournal of applied physiology (Bethesda, Md. : 1985)
dc.source.volume104
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2035
dc.identifier.contextkey1063418
html.description.abstract<p>Ten healthy human volunteers were subjected to progressive lower body negative pressure (LBNP) to the onset of cardiovascular collapse to compare the response of noninvasively determined skin and fat corrected deep muscle oxygen saturation (SmO2) and pH to standard hemodynamic parameters for early detection of imminent hemodynamic instability. Muscle SmO2 and pH were determined with a novel near infrared spectroscopic (NIRS) technique. Heart rate (HR) was measured continuously via ECG, and arterial blood pressure (BP) and stroke volume (SV) were obtained noninvasively via Finometer and impedance cardiography on a beat-to-beat basis. SmO2 and SV were significantly decreased during the first LBNP level (-15 mmHg), whereas HR and BP were late indicators of impending cardiovascular collapse. SmO2 declined in parallel with SV and inversely with total peripheral resistance, suggesting, in this model, that SmO2 is an early indicator of a reduction in oxygen delivery through vasoconstriction. Muscle pH decreased later, suggesting an imbalance between delivery and demand. Spectroscopic determination of SmO2 is noninvasive and continuous, providing an early indication of impending cardiovascular collapse resulting from progressive reduction in central blood volume.</p>
dc.identifier.submissionpathoapubs/2035
dc.contributor.departmentDepartment of Anesthesiology
dc.source.pages475-81


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