Pancreatic neuroendocrine tumors: the impact of surgical resection on survival
Authors
Hill, Joshua S.McPhee, James T.
McDade, Theodore P.
Zhou, Zheng
Sullivan, Mary E.
Whalen, Giles F.
Tseng, Jennifer F.
UMass Chan Affiliations
Department of SurgeryDocument Type
Journal ArticlePublication Date
2009-01-09Keywords
AgedFemale
Health Planning Guidelines
Humans
Male
Middle Aged
Neoplasm Staging
Neuroendocrine Tumors
Pancreatic Neoplasms
Prognosis
Risk Factors
SEER Program
Survival Rate
Treatment Outcome
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
BACKGROUND: Although surgical resection is generally recommended for patients with localized pancreatic neuroendocrine tumors (PNETs), the impact of resection on overall survival is unknown. The authors investigated the survival advantage of pancreatic resection using a national database. METHODS: This is a retrospective survival analysis of patients with PNETs from the Surveillance, Epidemiology, and End Results database (1988-2002). RESULTS: A total of 728 patients with PNETs were identified with a median survival of 43 months using Kaplan-Meier survival methods. Resection of tumor was associated with significantly improved survival compared with those patients who were recommended for but did not undergo resection (114 months vs 35 months; P < .0001). This survival benefit was demonstrated for patients with localized, regional, and metastatic disease. A multivariable Cox proportional hazards model was constructed to assess the overall effect of surgical resection on survival, and demonstrated an adjusted odds ratio of 0.48 (95% confidence interval, 0.35-0.66) compared with those who were recommended for surgery but did not proceed to surgery. CONCLUSIONS: The authors have demonstrated in a large national study that resection of primary tumor in patients with PNETs is associated with improved survival across all disease stages. Patients with localized, regional, and metastatic PNETs who are reasonable operative candidates should be considered for resection of their primary tumors.Source
Cancer. 2009 Feb 15;115(4):741-51. Link to article on publisher's siteDOI
10.1002/cncr.24065Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39303PubMed ID
19130464Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/cncr.24065