Survivin as a global target of intrinsic tumor suppression networks
Altieri, Dario C.
UMass Chan AffiliationsDepartment of Cancer Biology
Document TypeJournal Article
Gene Expression Regulation, Neoplastic
Tumor Suppressor Proteins
Medicine and Health Sciences
MetadataShow full item record
AbstractDespite the constant exposure to genomic insults that may lead to malignancy, cancer is surprisingly a relatively rare occurrence, and this is largely credited to an elaborate network of endogenous tumor suppression. Many effectors of tumor suppression have been identified, and their functions when activated in damaged cells have in large part been elucidated. What is less clear is whether there are common target gene(s) of tumor suppression, whose expression must be ablated in order to block transformation and preserve cellular homeostasis. Fresh experimental evidence suggests that silencing of the mitotic regulator and cell death inhibitor, survivin, is a universal requirement for successful tumor suppression in humans.
SourceCell Cycle. 2009 Sep 1;8(17):2708-10. Epub 2009 Sep 7. Link to article on publisher's website
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/39313
Co-author Minakshi Guha is a student in the Cancer Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related ResourcesLink to Article in PubMed