Tissue damage-induced intestinal stem cell division in Drosophila
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UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2009-01-09Keywords
AnimalsApoptosis
Basement Membrane
Bleomycin
Cell Count
Cell Differentiation
Cell Division
Cell Lineage
Cell Proliferation
Dextran Sulfate
Drosophila Proteins
Drosophila melanogaster
Enterocytes
Insulin
Intestines
Models, Biological
Receptor, Insulin
Signal Transduction
Stem Cells
Life Sciences
Medicine and Health Sciences
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Show full item recordAbstract
Stem cell division is essential for tissue integrity during growth, aging, and pathogenic assaults. Adult gastrointestinal tract encounters numerous stimulations, and impaired tissue regeneration may lead to inflammatory diseases and cancer. Intestinal stem cells in adult Drosophila have recently been identified and shown to replenish the various cell types within the midgut. However, it is not known whether these intestinal stem cells can respond to environmental challenges. By feeding dextran sulfate sodium and bleomycin to flies and by expressing apoptotic proteins, we show that Drosophila intestinal stem cells can increase the rate of division in response to tissue damage. Moreover, if tissue damage results in epithelial cell loss, the newly formed enteroblasts can differentiate into mature epithelial cells. By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division.Source
Cell Stem Cell. 2009 Jan 9;4(1):49-61. Link to article on publisher's site
DOI
10.1016/j.stem.2008.10.016Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39317PubMed ID
19128792Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.stem.2008.10.016