UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyDepartment of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal ArticlePublication Date
2009-12-04Keywords
Adaptor Proteins, Signal TransducingAnimals
Caspase 1
Humans
Immunity, Innate
Inflammation
Inflammation Mediators
Interleukin-1
Macromolecular Substances
Models, Immunological
Receptors, Immunologic
Signal Transduction
Immunology and Infectious Disease
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Inflammation is the coordinated immune response to harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue responses. These cells are equipped with an array of signaling receptors that detect foreign molecular substances or altered endogenous molecules that appear under situations of stress. This review provides an overview of recent progress in elucidating the molecular mechanisms that lead to inflammatory reactions. We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed "inflammasomes," which regulate the activity of caspase-1 and the maturation and release of IL-1beta.Source
J Clin Invest. 2009 Dec;119(12):3502-11. doi: 10.1172/JCI40599. Epub 2009 Dec 1. Link to article on publisher's siteDOI
10.1172/JCI40599Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39354PubMed ID
19955661Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1172/JCI40599