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    Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells

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    Authors
    Guay, Heath M.
    Mishra, Rabinarayan
    Garcea, Robert L.
    Welsh, Raymond M.
    Szomolanyi-Tsuda, Eva
    UMass Chan Affiliations
    Department of Molecular Genetics and Microbiology
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    2009-06-23
    Keywords
    Acute Disease
    Adoptive Transfer
    Animals
    Antibodies, Viral
    Antigens, T-Independent
    B-Lymphocyte Subsets
    Clone Cells
    Immunoglobulin G
    Immunoglobulin M
    Immunophenotyping
    Lymphoma, B-Cell, Marginal Zone
    Mice
    Mice, Inbred C57BL
    Mice, Knockout
    Mice, SCID
    Polyomavirus Infections
    Spleen
    Survival Analysis
    T-Lymphocyte Subsets
    Life Sciences
    Medicine and Health Sciences
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774789/
    Abstract
    B cells generated in the bone marrow of adult mice enter the periphery as transitional B cells and subsequently differentiate into one of two phenotypically and functionally distinct subsets, marginal zone (MZ) or follicular (Fo) B cells. Recent reports indicate, however, that in response to environmental cues, such as lymphopenia, mature Fo B cells can change to display phenotypic markers characteristic of MZ B cells. Previously, we found that splenic B cells transferred to SCID mice responded to polyoma virus (PyV) infection with T cell-independent (TI) IgM and IgG secretion, reducing the viral load and protecting mice from the lethal effect of the infection. The contribution of MZ and Fo B cell subsets to this antiviral TI-2 response, however, has not been addressed. In this study, we show that both sort-purified MZ and Fo B cells generate protective TI Ab responses to PyV infection when transferred into SCID mice. Moreover, the transferred Fo B cells in the spleens of the PyV-infected SCID mice change phenotype, with many of them displaying MZ B cell characteristics. These findings demonstrate the plasticity of the B cell subsets in virus-infected hosts and show for the first time that B cells derived exclusively from Fo B cells can effectively function in antiviral TI-2 responses.
    Source

    J Immunol. 2009 Jul 1;183(1):518-23. Link to article on publisher's site

    DOI
    10.4049/jimmunol.0900068
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/39362
    PubMed ID
    19542462
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.4049/jimmunol.0900068
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