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dc.contributor.authorMarfella, Concetta G. A.
dc.contributor.authorHenninger, Nils
dc.contributor.authorLeBlanc, Scott E.
dc.contributor.authorKrishnan, Namrata
dc.contributor.authorGarlick, David S.
dc.contributor.authorHolzman, Lawrence B.
dc.contributor.authorImbalzano, Anthony N.
dc.date2022-08-11T08:09:39.000
dc.date.accessioned2022-08-23T16:39:00Z
dc.date.available2022-08-23T16:39:00Z
dc.date.issued2008-12-15
dc.date.submitted2010-04-01
dc.identifier.citationKidney Blood Press Res. 2008;31(6):421-32. <a href="http://dx.doi.org/10.1159/000190788">Link to article on publisher's site</a>
dc.identifier.issn1420-4096 (Linking)
dc.identifier.doi10.1159/000190788
dc.identifier.pmid19142019
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39374
dc.description.abstractBACKGROUND AND AIMS: Glomerular diseases are the third leading cause of kidney failure worldwide, behind only diabetes and hypertension. The molecular mechanisms underlying the cause of glomerular diseases are still largely unknown. The identification and characterization of new molecules associated with glomerular function should provide new insights into understanding the diverse group of glomerular diseases. The Chd2 protein belongs to a family of enzymes involved in ATP-dependent chromatin remodeling, suggesting that it likely functions as an epigenetic regulator of gene expression via the modification of chromatin structure. METHODS: In this study, we present a detailed histomorphologic characterization of mice containing a mutation in the chromodomain helicase DNA-binding protein 2 (Chd2). RESULTS: We show that Chd2-mutant mice present with glomerulopathy, proteinuria, and significantly impaired kidney function. Additionally, serum analysis revealed decreased hemoglobin and hematocrit levels in Chd2-mutant mice, suggesting that the glomerulopathy observed in these mice is associated with anemia. CONCLUSION: Collectively, the data suggest a role for the Chd2 protein in the maintenance of kidney function.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=19142019&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818461/pdf/kbr0031-0421.pdf
dc.subjectAnimals
dc.subject*Chromatin Assembly and Disassembly
dc.subjectDNA-Binding Proteins
dc.subjectEpigenesis, Genetic
dc.subjectGlomerulonephritis, Membranous
dc.subjectKidney
dc.subjectKidney Diseases
dc.subjectMice
dc.subject*Mutation
dc.subjectPhenotype
dc.subjectProteinuria
dc.subjectCell Biology
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNephrology
dc.titleA mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype
dc.typeJournal Article
dc.source.journaltitleKidney and blood pressure research
dc.source.volume31
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2171
dc.identifier.contextkey1257948
html.description.abstract<p>BACKGROUND AND AIMS: Glomerular diseases are the third leading cause of kidney failure worldwide, behind only diabetes and hypertension. The molecular mechanisms underlying the cause of glomerular diseases are still largely unknown. The identification and characterization of new molecules associated with glomerular function should provide new insights into understanding the diverse group of glomerular diseases. The Chd2 protein belongs to a family of enzymes involved in ATP-dependent chromatin remodeling, suggesting that it likely functions as an epigenetic regulator of gene expression via the modification of chromatin structure.</p> <p>METHODS: In this study, we present a detailed histomorphologic characterization of mice containing a mutation in the chromodomain helicase DNA-binding protein 2 (Chd2).</p> <p>RESULTS: We show that Chd2-mutant mice present with glomerulopathy, proteinuria, and significantly impaired kidney function. Additionally, serum analysis revealed decreased hemoglobin and hematocrit levels in Chd2-mutant mice, suggesting that the glomerulopathy observed in these mice is associated with anemia.</p> <p>CONCLUSION: Collectively, the data suggest a role for the Chd2 protein in the maintenance of kidney function.</p>
dc.identifier.submissionpathoapubs/2171
dc.contributor.departmentDepartment of Internal Medicine, Division of Renal Medicine
dc.contributor.departmentDepartment of Cancer Biology
dc.contributor.departmentDepartment of Neurology
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages421-32


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