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dc.contributor.authorGupta, Sneha
dc.contributor.authorMcCollum, Dannel
dc.date2022-08-11T08:09:40.000
dc.date.accessioned2022-08-23T16:39:22Z
dc.date.available2022-08-23T16:39:22Z
dc.date.issued2011-11-11
dc.date.submitted2012-03-22
dc.identifier.citationCell Div. 2011 Nov 11;6:19. <a href="http://dx.doi.org/10.1186/1747-1028-6-19" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn1747-1028 (Linking)
dc.identifier.doi10.1186/1747-1028-6-19
dc.identifier.pmid22079013
dc.identifier.pmid22079013
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39457
dc.description<p>First author Sneha Gupta is a doctoral student in the Interdisciplinary Graduate Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.</p>
dc.description.abstractRegulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively. Our understanding of how these signaling pathways are coordinated to assist transition between the two cell-cycle stages is limited. Here, we review work from our laboratory, which reveals that cross talk between the SIN and MOR pathways is required for inhibition of interphase polarity programs during cytokinesis. Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22079013&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1186/1747-1028-6-19
dc.rights© 2011 Gupta and McCollum; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<a href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</a>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subjectCell Cycle Checkpoints
dc.subjectCytokinesis
dc.subjectActin Cytoskeleton
dc.subjectProtein-Serine-Threonine Kinases
dc.subjectCell Polarity
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.titleCrosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements
dc.typeJournal Article
dc.source.journaltitleCell division
dc.source.volume6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3252&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2253
dc.identifier.contextkey2691089
refterms.dateFOA2022-08-23T16:39:22Z
html.description.abstract<p>Regulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively. Our understanding of how these signaling pathways are coordinated to assist transition between the two cell-cycle stages is limited. Here, we review work from our laboratory, which reveals that cross talk between the SIN and MOR pathways is required for inhibition of interphase polarity programs during cytokinesis. Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms.</p>
dc.identifier.submissionpathoapubs/2253
dc.contributor.departmentProgram in Cell Dynamics
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.source.pages19


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