Characteristics, Practice Patterns, and Outcomes in Patients with Acute Hypertension: European Registry for Studying the Treatment of Acute HyperTension (Euro-STAT)
Payen de La Garanderie, Didier
Anderson, Frederick A. Jr.
Emery, Leigh A.
Gore, Joel M.
UMass Chan AffiliationsDepartment of Medicine, Division of Cardiovascular Medicine
Department of Quantitative Health Sciences
Center for Outcomes Research
Health Services Research
Medicine and Health Sciences
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AbstractINTRODUCTION: Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life' management practices and outcomes in patients who received intravenous antihypertensive therapy to treat an episode of acute hypertension. METHODS: Euro-STAT is a European, hospital-based, observational study of consecutive adult patients treated with intravenous antihypertensive therapy while in the emergency department, perioperative unit or ICU. Enrolment took place between 1 July and 15 October 2009 in 11 hospitals in 7 European countries (Austria, Belgium, Germany, Italy, Spain, Sweden and the United Kingdom). RESULTS: The study population was composed of 791 consecutive patients (median age 69 years, 37% women). Median arterial blood pressure before treatment was 166 mmHg systolic blood pressure (IQR 141 to 190 mmHg) and 80 mmHg diastolic blood pressure (IQR 68 to 95). Nitroglycerine was the most commonly used antihypertensive treatment overall (40% of patients), followed by urapidil (21%), clonidine (16%) and furosemide (8%). Treatment was associated with hypotension in almost 10% of patients. Overall 30-day mortality was 4%, and new or worsening end-organ damage occurred in 19% of patients. CONCLUSIONS: High blood pressure requiring intravenous therapy is currently managed with a variety of agents in Europe, with those most commonly used being nitroglycerine, urapidil and clonidine. Patients with acute hypertension have substantial concomitant morbidity and mortality, and intravenous antihypertensive treatment is associated with hypotension in almost 10% of cases.
SourceCrit Care. 2011 Nov 16;15(6):R271. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/39499
PubMed ID22087790; 22087790
Related ResourcesLink to Article in PubMed
© 2011 Vuylsteke et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.