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Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants

dc.contributor.authorWang, Jennifer P.
dc.contributor.authorZhang, Lei
dc.contributor.authorMadera, Rachel F.
dc.contributor.authorWoda, Marcia
dc.contributor.authorLibraty, Daniel H.
dc.date2022-08-11T08:09:40.000
dc.date.accessioned2022-08-23T16:39:39Z
dc.date.available2022-08-23T16:39:39Z
dc.date.issued2012-07-06
dc.date.submitted2012-08-27
dc.identifier.citationBMC Immunol. 2012 Jul 6;13:35. <a href="http://dx.doi.org/10.1186/1471-2172-13-35" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn1471-2172 (Linking)
dc.identifier.doi10.1186/1471-2172-13-35
dc.identifier.pmid22769054
dc.identifier.urihttp://hdl.handle.net/20.500.14038/39520
dc.description.abstractBACKGROUND: Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs). RESULTS: In this study, we identified sex differences in human infant pDC interferon-alpha production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-alpha production following R-848 challenge. CONCLUSIONS: Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22769054&dopt=Abstract">Link to Article in PubMed</a>
dc.rights© 2012 Wang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subjectInterferon-alpha
dc.subjectDendritic Cells
dc.subjectImidazoles
dc.subjectImmunology and Infectious Disease
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titlePlasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants
dc.typeJournal Article
dc.source.journaltitleBMC immunology
dc.source.volume13
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3314&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/2314
dc.identifier.contextkey3266144
refterms.dateFOA2022-08-23T16:39:39Z
html.description.abstract<p>BACKGROUND: Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs).</p> <p>RESULTS: In this study, we identified sex differences in human infant pDC interferon-alpha production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-alpha production following R-848 challenge.</p> <p>CONCLUSIONS: Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.</p>
dc.identifier.submissionpathoapubs/2314
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages35


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