Concurrent acute myeloid leukemia and T lymphoblastic lymphoma in a patient with rearranged PDGFRB genes
UMass Chan AffiliationsDepartment of Medicine
Document TypeJournal Article
Antineoplastic Combined Chemotherapy Protocols
Combined Modality Therapy
Graft vs Host Disease
Leukemia, Myeloid, Acute
Neoplasms, Multiple Primary
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Receptor, Platelet-Derived Growth Factor beta
Stem Cell Transplantation
Medicine and Health Sciences
MetadataShow full item record
AbstractConcurrent hematologic malignancies are relatively rare. We encountered a case of concurrent acute myeloid leukemia (AML) and T lymphoblastic lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(5;12)(q33;p13), which indicated presence of PDGFRB gene translocations. Therefore, this disease belongs to the new WHO category of myeloid and lymphoid neoplasms with abnormalities in PDGFRA, PDGFRB and FGFR1 genes. Although such genetic mutations are prone to multi-lineage differentiation, the present case is in fact the first report of concurrent AML and T lymphoblastic lymphoma involving PDGFRB mutations. The patient was treated with cytarabine and daunomycin in combination with high dose dexamethasone. Allogeneic stem cell transplantation was performed after successful remission induction for both entities. The patient eventually died of chronic graft-versus-host-disease related infection. Based on such an experience, we suggest the decision of stem cell transplantation should be weighed carefully against the risks, especially when tyrosine kinase inhibitors are safe and potentially effective in dealing with such entities.
SourceDiagn Pathol. 2012 Feb 22;7:19. Link to article on publisher's site 2012 Chang et al; licensee BioMed Central Ltd.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/39531
Related ResourcesLink to Article in PubMed
Rights© 2012 Chang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.