Scaling behavior of human locomotor activity amplitude: association with bipolar disorder
Authors
Indic, PremanandaSalvatore, Paola
Maggini, Carlo
Ghidini, Stefano
Ferraro, Gabriella
Baldessarini, Ross J.
Murray, Greg
UMass Chan Affiliations
Department of NeurologyDocument Type
Journal ArticlePublication Date
2011-06-01Keywords
AdolescentAdult
Bipolar Disorder
Female
Humans
Male
Middle Aged
Motor Activity
Young Adult
Life Sciences
Medicine and Health Sciences
Neurology
Metadata
Show full item recordAbstract
Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.Source
Indic P, Salvatore P, Maggini C, Ghidini S, Ferraro G, et al. (2011) Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder. PLoS ONE 6(5): e20650. doi:10.1371/journal.pone.0020650. Link to article on publisher's siteDOI
10.1371/journal.pone.0020650Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39564PubMed ID
21655197Related Resources
Link to Article in PubMedRights
Copyright: © 2011 Indic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0020650