UMass Chan Affiliations
Department of PathologyDocument Type
Journal ArticlePublication Date
2011-12-01Keywords
AnimalsCD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Granzymes
Histocompatibility Antigens Class II
Humans
Immune System
Lysosomal-Associated Membrane Protein 1
Mice
Models, Biological
Phenotype
T-Lymphocytes, Cytotoxic
Immunology and Infectious Disease
Immunopathology
Metadata
Show full item recordAbstract
CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in humans, mice, and other species in response to many diverse pathogens. Since CD4 cytotoxic T cells are able to recognize antigenic determinants unique from those recognized by the parallel CD8 cytotoxic T cells, they can potentially contribute additional immune surveillance and direct effector function by lysing infected or malignant cells. Here, we briefly review much of what is known about the generation of cytotoxic CD4 T cells and describe our current understanding of their role in antiviral immunity. Furthering our understanding of the many roles of CD4 T cells during an anti-viral response is important for developing effective vaccine strategies that promote long-lasting protective immunity.Source
J Biomed Biotechnol. 2011;2011:954602. doi: 10.1155/2011/954602. Link to article on publisher's siteDOI
10.1155/2011/954602Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39602PubMed ID
22174559Related Resources
Link to Article in PubMedRights
Copyright © 2011 N. B. Marshall and S. L. Swain. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ae974a485f413a2113503eed53cd6c53
10.1155/2011/954602